长白母猪断奶至配种间隔全基因组关联分析  

A Genome􀆼wide Association Study in Landrace Sows during Weaning􀆼to􀆼service Interval

作　　者：陈信佑 林清 张笑科 李婷婷 万鹏冲 林长光[2] 黄珍 谢水华 张豪[1] 李加琪[1] CHEN Xinyou;LIN Qing;ZHANG Xiaoke;LI Tingting;WAN Pengchong;LIN Changguang;HUAGN Zhen;XIE Shuihua;ZHANG Hao;LI Jiaqi(College of Animal Science,South China Agricultural University/Guangdong Key Laboratory of Agro-Animal Genomics and Molecular Breeding/National Engineering Research Center for Swine Breeding Industry,Guangzhou Guangdong 510642;Institute of Animal Husbandry and Veterinary,Fujian Academy of Agricultural Science,Fuzhou Fujian 350013;Guangdong iPig Technology Co.,Ltd,Guangzhou Guangdong 510405;Agro􀆼Tech Extension Center of Guangdong Province,Guangzhou Guangdong 510520)

机构地区：[1]华南农业大学动物科学学院/广东省农业动物基因组学与分子育种重点实验室/国家生猪种业工程技术研究中心,广东广州510642 [2]福建省农业科学院畜牧兽医研究所,福建福州350013 [3]广东艾佩克科技有限公司,广东广州510405 [4]广东省农业技术推广中心,广东广州510520

出　　处：《广东畜牧兽医科技》2023年第3期30-34,41,共6页Guangdong Journal of Animal and Veterinary Science

基　　金：国家生猪产业技术体系(CARS-35)。

摘　　要：该研究旨通过全基因组关联分析定位影响长白母猪断奶至配种间隔的候选基因,以期为我国种猪育种工作提供理论参考。本研究以国家某核心育种场1063头长白母猪的断奶至配种间隔记录和50 K基因数据为研究材料,利用GEMMA软件的混合线性模型进行全基因组关联分析(GWAS),鉴定关联分析显著位点。结果表明,长白母猪第一胎次和第三胎次共存在5个显著SNPs。对5个显著位点进行单倍型分析,获得4个单倍型块。筛选到的BTG1、FUT1、FUT2、SCNN1G和CBLB基因可能是影响断奶至配种间隔性状的重要基因,该研究结果可作为以后种猪育种实践提供参考。The aim of this study was to detect candidate genes affecting the weaning⁃to⁃service interval of Landrace sows through the genome⁃wide association analysis(GWAS),in order to provide theoretical references for swine breeding in China.In this study,the weaning⁃to⁃service interval records and 50K gene data of 1063 Landrace sows in a core breeding farm in China were used as research materials,and genome⁃wide association analysis was performed by mixed linear models of GEMMA software to identify important loci.The results showed that there were 5 significant SNPs in the first and third parity of Landrace sows.Haplotype analysis was performed on the 5 significant locus and 4 haplotype blocks were obtained.The screened genes of BTG1,FUT1,FUT2,SCNN1G,and CBLB may be the important genes affecting the weaning⁃to⁃servce interval traits.The results of this study can provide the reference for future practice of swine breeding.

关 键 词：全基因组关联分析 断配间隔 GEMMA 长白猪 

分 类 号：S814[农业科学—畜牧学]