前驱期阿尔茨海默病的简易筛查中国专家共识(2023年版)  

Chinese expert consensus on brief screening of prodromal Alzheimer's disease(2023)

作　　者：中华医学会神经病学分会痴呆与认知障碍学组 中国医师协会神经内科医师分会认知障碍疾病专业委员会 陈晓春[2] 贾建平[3] 郭起浩 黄琳 李沁洁 陆瑶 潘锋丰 崔亮 王莹[4] 苗雅 陈天璐 李亚天 吴静楠 Dementia and Cognitive Impairment Group of Chinese Society of Neurology;Cognitive Disorders Committee of Neurology Branch of Chinese Medical Doctor Association;Chen Xiaochun;Jia Jianping;Guo Qihao(不详;Department of Neurology,Union Hospital Affiliated to Fujian Medical University,Fuzhou 350001,China;Innovation Center for Neurological Disorders and Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Geriatrics,Sixth People's Hospital Affiliated to School of Medicine of Shanghai Jiaotong University,Shanghai 200233,China)

机构地区：[1]不详 [2]福建医科大学附属协和医院神经内科,福州350001 [3]首都医科大学宣武医院神经科、神经疾病高创中心,北京100053 [4]上海交通大学医学院附属第六人民医院老年病科,上海200233 [5]博斯腾脑科学研究中心

出　　处：《中华神经医学杂志》2023年第5期433-444,共12页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金面上项目(82171198);国家自然科学基金区域创新发展联合基金重点项目(U20A20354);国家科技部科技创新2030-重大项目子课题(2022ZD0211603)。

摘　　要：阿尔茨海默病(AD)是一种常见的老年性神经退行性疾病,前驱期AD(pAD)的诊断与干预是目前临床与医学研究关注的焦点,此阶段包括β-淀粉样蛋白(Aβ)阳性的认知功能正常人群,也包括AD源轻度认知损害(MCI)患者,对其及时干预有可能减缓甚至终止向痴呆阶段的进程。但现有的检查由于其有创性(脑脊液检测)或费用昂贵(PET扫描)而难以普及。因此,研发简便有效、低成本、无创的pAD筛查方法意义重大。本共识总结了目前国际上有关pAD的筛查方法和此阶段相关的标志物,希望能够指导pAD的早期识别与诊断,进而深化AD的进一步研究与临床实践。Alzheimer's disease(AD)is a common degenerative disease in the elderly.Current clinic and medical research maily focus on diagnosis and intervention of prodromal Alzheimer's disease(pAD),including subjects with beta-amyloid(Aβ)-positive deposition and normal cognition and patients with AD-originated mild cognitive impairment(MCI);timely intervention may slow or even terminate AD progression into dementia stage.Existing invasive test(CSF)or expensive test(PET)could not be wildly used,so a simple,effective,low-cost and non-invasive screening method for pAD is of great significance.This consensus summarizes current international screening methods for pAD and related markers at this stage,which are expected to guide early identification and diagnosis of pAD,deepen further research and clinical practice on AD.

关 键 词：阿尔茨海默病 Β-淀粉样蛋白 早期诊断 生物标志物 专家共识 

分 类 号：R749.16[医药卫生—神经病学与精神病学]