含炔烃的氨基酸酯的简便合成研究  

Simple Synthesis of Amino Acid Esters Containing Alkynes

作　　者：谭靖颖 洪玉 刘宇轩 唐石[1] TAN Jingying;HONG Yu;LIU Yuxuan;TANG Shi(College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,China)

机构地区：[1]吉首大学化学化工学院,湖南吉首416000

出　　处：《化工技术与开发》2023年第6期14-16,共3页Technology & Development of Chemical Industry

摘　　要：本文探究了一种含炔烃官能团的氨基酸酯衍生物的简便合成方法。起始原料为丝氨酸甲酯盐酸盐,经胺醛缩合、取代反应、Sonogashira反应、Appel溴化反应,成功制备了(2-(3-苯基丙基-2-炔基)氨基)-3-溴丙酸甲酯。此研究为含炔烃官能团的氨基酸衍生物的合成提供了便利途径,具有较好的应用前景。In this paper,a simple synthesis method of amino acid ester derivatives containing alkyne functional groups was studied.The starting material of this synthesis route was serine methyl ester hydrochloride,and(2-(3-phenylpropyl-2-alkynyl)amino)-3-bromopropionic acid methyl ester was successfully prepared through four steps of amine aldehyde condensation,substitution reaction,Sonogashira reaction and Appel bromination reaction.This study provided a convenient way for the synthesis of amino acid derivatives containing alkyne functional groups.

关 键 词：钯催化 SONOGASHIRA反应 还原交叉偶联 胺醛缩合 

分 类 号：O621.3[理学—有机化学]