无水乙醇注射辅助射频消融治疗危险部位肝细胞癌的长期疗效:倾向性匹配评分研究  

Long-term Efficacy of Absolute Ethanol Injection-assisted Radiofrequency Ablation in the Treatment of Risk-site Hepatocellular Carcinoma:A Propensity-Matched Score Study

作　　者：牟洋[1] 王彪[1] 马媛媛 翟虹[1] MU Yang;WANG Biao;MA Yuanyuan(Department of Medical Ultrasonics,Affiliated Hospital of Traditional Chinese Medicine,Xinjiang Medical University,Xinjiang 830099,China)

机构地区：[1]新疆医科大学附属中医医院超声科,乌鲁木齐830099

出　　处：《医学研究杂志》2023年第6期78-82,共5页Journal of Medical Research

基　　金：新疆维吾尔自治区自然科学基金资助项目(2021D01C223)。

摘　　要：目的通过倾向性评分匹配(propensity score matching,PSM)后比较危险部位和非危险部位的肝细胞癌(subcapsular hepatocellular carcinoma,HCC)射频消融的长期疗效。方法2016年10月~2022年1月期间,筛选出181例符合标准的射频消融病例,通过倾向性匹配评分匹配了32对,即对照组32例、干预组(无水乙醇注射)32例。评估两组间局部肿瘤进展(local tumor progression,LTP)、无进展生存率(progress free survival,PFS)、总生存率(overall survival,OS)等疗效指标。结果对照组1年、3年和5年的PFS分别为88%、44%和44%,干预组分别为94%、52%和38%;对照组1年、3年和5年的OS分别为100%、92%和87%,干预组分别为94%、78%和66%。此外,两组的LTP发生率、严重并发症发生率、技术成功率、术后住院时间、技术有效率间比较,差异无统计学意义(P>0.05)。结论无水乙醇注射辅助经皮射频消融术作为危险部位HCC一线治疗手段,具有很好的临床疗效及安全性。Objective To compare the long-term efficacy of radiofrequency ablation of dangerous and non-dangerous hepatocellular carcinoma(HCC)using propensity score matching(PSM).Methods From October 2016 to January 2022,181 radiofrequency ablation cases met the standard,and 32 pairs were matched by PMS,32 cases in the control group and 32 cases in the intervention group(absolute alcohol injection).Local tumor progression(LTP),progress free survival(PFS),and overall survival(OS)were evaluated between the two groups.Results The PFS in the control group were 88%,44%and 44%at 1,3 and 5 years respectively,and in the interventional group were 94%,52%and 38%respectively;the OS in the control group at 1,3 and 5 years were 100%,92%and 87%respectively,and those in the intervention group were 94%,78%and 66%respectively.In addition,there was no significant difference between the two groups in the incidence of LTP,the incidence of serious complications,technical success rate,the postoperative length of stay,and technical efficiency(P>0.05).Conclusion As a first-line treatment for HCC at dangerous sites,percutaneous radiofrequency ablation assisted by ethanol injection has good clinical efficacy and safety.

关 键 词：肝细胞癌 射频消融 无水乙醇 倾向性匹配评分 

分 类 号：R735.7[医药卫生—肿瘤] R445.1[医药卫生—临床医学]