超声差分衰减截距成像监测高强度聚焦超声致热损伤  

Ultrasonic differential attenuation intercept imaging formonitoring high-intensity focused ultrasoundinduced thermal damage

作　　者：徐佳虹 杨昆 史新旺 陈丹 周小伟 XU Jiahong;YANG Kun;SHI Xinwang;CHEN Dan;ZHOU Xiaowei(College of Biomedical Engineering,Chongqing Medical University,State Key Laboratory of Ultrasound in Medicine and Engineering,Chongqing 400016,China;School of Microelectronics,Tianjin University,Tianjin 300072,China)

机构地区：[1]重庆医科大学生物医学工程学院超声医学工程国家重点实验室,重庆400016 [2]天津大学微电子学院,天津300072

出　　处：《中国医学影像技术》2023年第6期805-811,共7页Chinese Journal of Medical Imaging Technology

基　　金：重庆市自然科学基金面上项目(CSTB2022NSCQ-MSX0968);超声医学工程国家重点实验室开放课题资助项目(2022KFKT004)。

摘　　要：目的 观察以超声差分衰减截距成像监测高强度聚焦超声(HIFU)所致热损伤的可行性。方法 基于原始超声成像数据和声衰减截距数学模型开发超声差分衰减截距算法;分别以80、131、165和205 W声功率对离体猪里脊组织进行HIFU辐照,观察B型超声声像图、超声差分衰减截距图所见及猪里脊组织损伤,计算不同声功率HIFU辐照前、后热损伤区域即焦域的平均超声差分衰减截距(Δα_(0))、B型超声声像图和超声差分衰减截距图的对比度噪声比(CNR),绘制CNR动态变化曲线。结果 以80 W声功率辐照后,B型超声声像图中未见区别于背景的亮区,超声差分衰减截距图中焦域出现微弱亮区,猪里脊组织未见损伤区域;以131 W声功率辐照后,B型超声声像图中未见区别于背景的亮区,超声差分衰减截距图中见较小亮黄色区域,猪里脊组织见白色热损伤区;以165 W声功率辐照后,B型超声声像图中未见区别于背景的亮区,超声差分衰减截距图中出现亮点并于治疗结束时形成区别于背景的高亮区,猪里脊组织可见白色热损伤区;以205 W声功率辐照过程中,B型超声声像图中似见模糊微弱亮区但肉眼较难辨别,超声差分衰减截距图中可见明显高亮区且随消融时间延长而逐渐增大,猪里脊组织见白色热损伤区。至辐照结束时,131、165、205 W声功率超声差分衰减截距图的Δα_(0)平均值分别由0.04、0.07、0.10 dB/cm增至0.31、0.42、0.75 dB/cm。CNR动态变化曲线显示,131、165、205 W声功率超声差分衰减截距图的CNR曲线始终处于B型超声声像图的CNR曲线之上。结论 以超声差分衰减截距成像监测HIFU所致离体猪里脊组织热损伤可行,且监测效果优于B型超声。Objective To explore the feasibility of ultrasonic differential attenuation intercept imaging for monitoring thermal damage caused by high-intensity focused ultrasound(HIFU).Methods An ultrasonic differential attenuation intercept algorithm was developed based on the raw data of ultrasound imaging and the mathematical model of acoustic attenuation intercept.HIFU irradiations of isolated pork tenderloin tissue were performed with the acoustic power of 80,131,165 and 205 W,respectively.The manifestations on ultrasonic differential attenuation intercepts and ultrasound images during ablation processes,as well as the damage conditions of the pork tenderloin tissue after the ablation were observed.The average ultrasonic differential attenuation intercept(Δα_(0))of the thermal damage area before and after HIFU irradiation with different acoustic power and the contrast-to-noise ratio(CNR)of ultrasonic differential attenuation intercept images and ultrasound images were calculated,and the dynamic change curves of CNR were drawn.Results At the end of irradiation with 80 W,no bright area in the background was observed on ultrasonograms,through weak bright region appeared on the ultrasonic differential attenuation intercept image,no damaged area of pork tenderloin tissue was found.At the end of irradiation with 131 W,no bright area in the background was found on ultrasonograms,while a small bright yellow area was noticed on ultrasonic differential attenuation intercept image,and a heat damage area of pork tenderloin tissue was observed.During irradiation with 165 W,no bright area in the background was seen on ultrasonograms,but a bright spot developed on ultrasound differential attenuation intercept image and form a highlight area at the end of irradiation,and a white heat damage area was seen in pork tenderloin tissue.During irradiation with 205 W,a faint bright area appeared on ultrasonograms but was difficult to observe with naked eye,while on ultrasonic differential attenuation intercept image,the highlight area becam

关 键 词：高强度聚焦超声消融 热损伤 超声差分衰减截距成像 

分 类 号：R-33[医药卫生] R445.1