Xp11.2易位/TFE3基因融合相关性肾细胞癌^(18)F-FDG PET/CT特征  

^(18)F-FDG PET/CT characteristics of renal cell carcinomaassociated with Xp11.2 translocation/TFE3 gene fusion

作　　者：祝安惠[1] 张卫方[1] ZHU Anhui;ZHANG Weifang(Department of Nuclear Medicine,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院核医学科,北京100191

出　　处：《中国医学影像技术》2023年第6期885-889,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察Xp11.2易位/TFE3基因融合相关性肾细胞癌(Xp11.2易位肾细胞癌)PET/CT表现。方法回顾性分析6例Xp11.2易位肾细胞癌患者,观察其PET/CT表现。结果6例肿瘤最大径6.5~15.5 cm、中位最大径10.30 cm;5例呈高、低混杂密度肿块,1例呈均匀低密度;5例为囊实性、1例为实性肿块;5例^(18)F-FDG摄取增高,最大标准摄取值(SUV_(max))为2.5~6.5、中位数为6.2,1例^(18)F-FDG摄取低于相邻肾实质;5例肿瘤内或边缘可见散在点状/条状/结节状钙化灶;3例合并肾静脉/下腔静脉瘤栓,表现为静脉管腔增粗,放射性摄取增高;2例合并远处转移,分别为肺转移及肝、肺、骨多器官转移,均表现为不同程度放射性摄取增高。结论Xp11.2易位肾细胞癌PET/CT表现具有一定特征性,多呈较大软组织肿块伴囊变及钙化,^(18)F-FDG摄取多增高。Objective To observe the PET/CT manifestations of renal cell carcinoma(RCC)associated with Xp11.2 translocation/TFE 3 gene fusion(Xp11.2 translocation RCC).Methods Data of 6 patients with Xp11.2 translocation RCC were retrospectively analyzed,and the PET/CT manifestations of tumors were observed.Results The maximum diameter of 6 tumors was 6.5—15.5 cm,with the median maximum diameter of 10.30 cm.Among 6 cases,tumors presented as uneven mixed high and low density mass in 5 cases and uniform low density in 1 case,which was cystic solid mass in 5 cases but solid mass in 1 case.The degree of ^(18)F-FDG uptake increased of 5 cases,with the maximum standard uptake value(SUV max)of 2.5—6.5 and the median of 6.2,^(18)F-FDG uptake was lower than that of adjacent renal parenchyma while in 1 case.Calcifications presented as scattered punctate/strip/nodular calcifications in the tumor or at the edges were detected in 5 cases.Renal vein/inferior vena cava tumor thrombi were noticed in 3 cases,characterized by thickenen venous lumen and increased radiation uptake.Distant metastases occurred in 2 cases,including lung metastases and multiple organ metastases in liver,lung and bones,respectively,with varying degrees of increased radiation uptake.Conclusion PET/CT manifestations of Xp11.2 translocation RCC had certain characteristics,which mainly presented as large soft tissue masses with cystic changes,calcifications and increased ^(18)F-FDG uptake.

关 键 词：肾肿瘤 Xp11.2易位/TFE3基因融合 体层摄影术 X线计算机 正电子发射断层显像 

分 类 号：R737.11[医药卫生—肿瘤] R817.4[医药卫生—临床医学]