脑出血术后并发应激性溃疡的危险因素  

Risk Factors of Stress Ulcer after Intracerebral Hemorrhage Surgery

作　　者：王秋亚[1] 孙晓旭[1] 明帅 WANG Qiu-ya;SUN Xiao-xu;MING Shuai(The First Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450007)

机构地区：[1]郑州大学第一附属医院,河南郑州450007 [2]河南省人民医院,河南郑州450000

出　　处：《医学临床研究》2023年第5期717-719,723,共4页Journal of Clinical Research

摘　　要：【目的】探讨脑出血术后并发应激性溃疡(SU)的危险因素。【方法】回顾性分析2018年1月至2022年1月郑州大学第一附属医院收治374例接受手术治疗的脑出血患者的临床资料,根据术后是否并发SU将其分为SU组(n=42)和非SU组(n=332)。比较两组患者基线资料,采用Logistic多因素回归模型分析影响脑出血术后并发SU的危险因素。受试者工作特征(ROC)曲线分析Logistic多因素回归模型评估脑出血术后并发SU的价值。【结果】两组患者年龄及血清钾、胃泌素、乳酸水平比较,差异有统计学意义(P<0.05)。Logistic回归分析显示,年龄(≥60岁)及血清钾(≤3.84 mmol/L)、胃泌素(>73.17 ng/L)、乳酸(>2.70 mmol/L)是脑出血术后并发SU的危险因素(P<0.05)。Logistic回归模型评估脑出血术后并发SU的AUC为0.878(95%CI:0.824~0.936),敏感度为82.13%,特异度为83.66%。【结论】年龄及血清钾、胃泌素及乳酸水平为脑出血术后并发SU的重要影响因素,临床医师可针对性制定相应的干预措施,从而降低术后SU发生风险。【Objective】To explore the risk factors of stress ulcer(SU)after intracerebral hemorrhage surgery.【Methods】A retrospective analysis was conducted on the clinical data of 374 patients with cerebral hemorrhage who underwent surgical treatment at the First Affiliated Hospital of Zhengzhou University from January 2018 to January 2022.They were divided into an SU group(n=42)and a non SU group(n=332)based on whether they had postoperative complications.The baseline data of two groups of patients were compared and the logistic multiple factor regression model was used to analyze the risk factors of postoperative complications of cerebral hemorrhage.The ROC curve was used to analyze the value of logistic multivariate regression model in evaluating postoperative complications of cerebral hemorrhage.【Results】There were significant differences in age,serum potassium,Gastrin and lactic acid between the two groups(P<0.05).Logistic regression analysis showed that age(≥60 years old),serum potassium(≤3.84 mmol/L),Gastrin(>73.17 ng/L),and lactic acid(>2.70 mmol/L)were the risk factors for SU after intracerebral hemorrhage surgery(P<0.05).The AUC of the logistic regression model for evaluating postoperative complications of cerebral hemorrhage with SU was 0.878(95%CI:0.824-0.936),with a sensitivity of 82.13%and a specificity of 83.66%.【Conclusion】Age,serum potassium,Gastrin and lactic acid levels are important influencing factors for postoperative SU after intracerebral hemorrhage.Clinicians can formulate corresponding intervention measures to reduce the risk of postoperative SU.

关 键 词：脑出血/外科学 手术后并发症 消化性溃疡 危险因素 

分 类 号：R743.34[医药卫生—神经病学与精神病学]