妇科门诊女性HPV感染率和基因亚型分布与宫颈病变关系研究  

Study on the relationship between HPV infection rate,gene subtype distribution and cervical lesions in gynecological outpatient women

作　　者：郭慧芳 李兴坚 张攀 何丰利 刘正华 Guo Huifang;Li Xingjian;Zhang Pan;He Fengli;Liu Zhenghua(Department of Gynecology,the Fourth People's Hospital of Chenzhou,Chenzhou 423000,China)

机构地区：[1]郴州市第四人民医院妇科,湖南郴州423000

出　　处：《实用妇科内分泌电子杂志》2023年第3期12-14,共3页Electronic Journal of Practical Gynecological Endocrinology

基　　金：郴州市科技创新能力培育市级项目(编号ZDYF2020237)。

摘　　要：目的研究妇科门诊女性人乳头瘤病毒(HPV)感染率和基因亚型分布与宫颈病变之间的关系。方法选取576例接受HPV检测、宫颈薄层液基细胞学(TCT)检查的女性病例,针对检查异常者开展阴道镜活检确诊,统计HPV感染率,对HPV亚型分布情况进行统计,分析高危型HPV分布与宫颈病变之间的关系。结果576例患者中确定存在HPV感染者共计123例,HPV感染率为21.35%;HPV感染者的基因亚型分布中HPV 52、HPV 16、HPV 58的感染率占前3位。患者中存在宫颈病变者共计28例,占比4.86%,其中宫颈上皮内瘤变(CIN)Ⅰ病例10例,CINⅡ病例9例,CINⅢ病例6例,鳞状细胞癌(SCC)病例3例;相比CINⅠ而言,CINⅡ、CINⅢ、宫颈癌的HPV感染率更高,差异有统计学意义(P<0.05)。结论妇科门诊女性HPV感染率相对较高,高危型HPV感染与宫颈病变等级存在密切关系,临床加强HPV感染人群的早期宫颈病变筛查极为重要。Objective To study the relationship between human papillomavirus(HPV)infection rate,gene subtype distribution and cervical lesions in women in gynecological outpatient department.Methods A total of 576 female cases who received HPV test and cervical thin layer liquid based cytology(TCT)examination were selected,and colposcopy biopsy was carried out to confirm the diagnosis of abnormal examination.HPV infection rate was calculated,and the distribution of HPV subtypes was analyzed to analyze the relationship between high-risk HPV distribution and cervical lesions.Results A total of 123 of the 576 patients were confirmed to have HPV infection,and the HPV infection rate was 21.35%.The infection rate of HPV 52,HPV 16 and HPV 58 accounted for the top 3 in the distribution of gene subtypes of HPV infected people.There were 28 patients with cervical lesions,accounting for 4.86%,including 10 cases of cervical intraepithelial neoplasia(CINⅠ),9 cases of CINⅡ,6 cases of CINⅢ,and 3 cases of squamous cell carcinoma(SCC).Compared with CINⅠ,the HPV infection rate of CINⅡ,CINⅡand cervical cancer was higher,and the difference was statistically significant(P<0.05).Conclusion The HPV infection rate of women in gynecological outpatient department is relatively high,and there is a close relationship between high-risk HPV infection and cervical lesion grade.It is very important to strengthen the early cervical lesion screening of HPV infected population clinically.

关 键 词：妇科门诊 人乳头瘤病毒感染 基因亚型分布 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]