宫颈环形电切术联合阴道镜治疗宫颈癌前病变患者的临床疗效  

Clinical efficacy of loop electrosurgical excision procedure of cervix combined with colposcopy in the treatment of cervical precancerous lesion

作　　者：崔英[1] 青措吉 祁海兰 汪祖春 CUI Ying;QING Cuoji;QI Hailan;WANG Zuchun(Department of Gynecology,Qinghai Red Cross Hospital,Xining 810000,Qinghai,China)

机构地区：[1]青海红十字医院妇科,西宁810000

出　　处：《癌症进展》2023年第8期862-865,共4页Oncology Progress

摘　　要：目的探讨宫颈环形电切术(LEEP)联合阴道镜治疗宫颈癌前病变患者的临床疗效。方法根据手术术式的不同将80例宫颈癌前病变患者分为对照组和研究组,每组40例,对照组患者采用宫颈激光烧灼术治疗,研究组患者采用LEEP联合阴道镜治疗。比较两组患者的临床疗效、围手术期指标、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平、术后并发症发生率、复发率和高危型人乳头瘤病毒(HR-HPV)转阴率。结果研究组患者的总有效率为95.00%,高于对照组患者的77.50%,差异有统计学意义(P<0.05)。研究组患者的手术时间和术后阴道流液时间均短于对照组,术中出血量少于对照组,差异均有统计学意义(P<0.05)。术后7天,两组患者的TNF-α、IL-6、CRP水平均低于本组术前,研究组患者的TNF-α、IL-6、CRP水平均低于对照组,差异均有统计学意义(P<0.05)。研究组患者的术后并发症总发生率和术后1年复发率均低于对照组,术后1年HR-HPV转阴率高于对照组,差异均有统计学意义(P<0.05)。结论LEEP联合阴道镜治疗宫颈癌前病变患者能够提高临床疗效,缩短手术时间,减少术中出血量,减轻术后炎症反应,降低术后并发症发生率和复发率,促进HR-HPV转阴。Objective To explore the clinical efficacy of loop electrosurgical excision procedure of cervix(LEEP)combined with colposcopy in the treatment of cervical precancerous lesion.Method A total of 80 patients with cervical precancerous lesion were divided into control group(n=40,received cervical laser cauterization)and study group(n=40,received LEEP combined with colposcopy).The clinical efficacy,perioperative indexes,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)]levels,postoperative complications,recurrence rate,and negative conversion rate of high risk human papilloma virus(HR-HPV)in the two groups were compared.Result The total effective rate of the study group was 95.00%,higher than 77.50%of the control group(P<0.05).The operative time,postoperative vaginal fluid flowing time of the study group were shorter than those of the control group,and the intraoperative blood loss was less than that of the control group,the differences were statistically significant(P<0.05).Seven days after surgery,the TNF-α,IL-6 and CRP levels in both groups were lower than those before surgery,with lower levels in the study group than those in the control group(P<0.05).The total incidence of postoperative complications and recurrence rate 1 year after surgery in the study group were lower than those in the control group,and the HRHPV negative conversion rate 1 year after surgery was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion LEEP combined with colposcopy in the treatment of cervical precancerous lesion can improve the clinical efficacy,shorten the operation time,reduce intraoperative blood loss,postoperative inflammatory reaction and incidence of postoperative complications and recurrence rate,and promote the negative conversion of HRHPV.

关 键 词：宫颈癌前病变 宫颈环形电切术 阴道镜 临床疗效 

分 类 号：R737.33[医药卫生—肿瘤]