微生物表面活性素合成调控和高效生产研究进展  

Research Progress in Regulation and Efficient Production of Microbial Surfactin Synthesis

作　　者：刘青 刘波[2] 徐欣欣[2] 张红兵[1] 张宇宏[2] 张伟[2] LIU Qing;LIU Bo;XU Xinxin;ZHANG Hongbing;ZHANG Yuhong;ZHANG Wei(College of Biology Science and Engineering,Hebei University of Economics and Business,Shijiazhuang 050061,China;Biotechnology Research Institute,Chinese Academy of Agricultural Sciences,Beijing 100081,China)

机构地区：[1]河北经贸大学生物科学与工程学院,石家庄050061 [2]中国农业科学院生物技术研究所,北京100081

出　　处：《中国农业科技导报》2023年第4期23-31,共9页Journal of Agricultural Science and Technology

基　　金：中国农业科学院科技创新工程项目。

摘　　要：表面活性素是由芽孢杆菌属微生物次级代谢所产生的一类脂肽,具有多种生物活性,在食品、医药、日化、采油和生防等多个领域具有广阔的应用前景。但天然菌株产表面活性素效率低、生产成本高,严重限制了表面活性素的实际应用。对微生物表面活性素的结构性质、应用效果、合成途径调控进行了简要阐述,重点综述了提升其产量的多种策略,并对其高效生产和应用前景进行了展望。Surfactin is a kind of lipopeptide produced by the secondary metabolism of microorganisms of Bacillus,which has a variety of biological activities with a broad application prospect in many fields such as food,medicine,daily chemical,oil extraction and biological defense.However,the low production efficiency and high production cost of natural strains of Bacillus sp.have severely limited the practical application of surfactin.The structural properties,application effects and regulation of the microbial surfactin on synthesis pathway were briefly described.Several strategies for increasing the yield of microbial surfactin were emphatically reviewed,and the prospects of its efficient production and application was also prospected.

关 键 词：表面活性素 高效合成 基因工程 理性设计 

分 类 号：Q939.9[生物学—微生物学]