国家中药复方专利治疗偏头痛用药规律研究  

Medication Regularity of National Chinese Patent Compounds Against Migraine

作　　者：刘红喜 梁晓 申伟 魏竞竞 付国静 刘悦 迟显苏 张允岭 LIU Hong-xi;LIANG Xiao;SHEN Wei;WEI Jing-jing;FU Guo-jing;LIU Yue;CHI Xian-su;ZHANG Yun-ling(Graduate School,Beijing University of Chinese Medicine,Beijing 100029;Department of Encephalopathy,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中国中医科学院西苑医院脑病科,北京100091

出　　处：《世界中西医结合杂志》2023年第5期849-854,861,共7页World Journal of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局中医药传承与创新“百千万”人才工程项目(国中医药人教发[2018]12号);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202007);中医药防治脑病传承创新团队(CI2021B006);中国中医科学院科技创新工程项目(CI2021A01301)。

摘　　要：目的 基于数据挖掘技术对国家专利数据库中治疗偏头痛的中药复方配伍规律进行研究,为偏头痛的临床治疗及新药研发提供思路。方法 检索国家知识产权局中国专利公布公告网站建库至2022年5月1日治疗偏头痛的中药复方专利数据,运用古今医案云平台(V2.3.5)对筛选出的中药复方进行药物频次统计、性味归经统计、功效统计、关联分析、聚类分析、复杂网络分析等数据挖掘。结果 通过检索与筛选,共纳入符合标准的中药复方394首,涉及667味中药,药物总频次4737次。药物使用频次居前10位分别是川芎、白芷、天麻、甘草、当归、白芍、防风、细辛、菊花、柴胡。药物性味归经上,药性以温性为主,其次为平性、微寒等,药味以辛味为主,其次为甘味、苦味等,归经以肝经为主,其次为肺经、脾经、心经、胃经、肾经等。药物功效以祛风止痛、清热解毒、解表散寒、平抑肝阳、活血行气等使用频次较高。药物关联中高频药物组合有“川芎-白芷”“天麻-川芎”“当归-川芎”“细辛-川芎”“天麻-白芷”“细辛-白芷”等。药物聚类可将使用频次≥40次的27味高频中药聚类成6类。复杂网络分析筛选出治疗偏头痛的核心组方为:川芎、白芷、细辛、防风、天麻、当归、白芍、蔓荆子、柴胡、菊花、全蝎、甘草。结论 中药复方治疗偏头痛多以“风、瘀、毒”病机着手,注重祛邪达表、通络止痛、清解郁毒,常用祛风解表、活血行气、通络止痛、养血滋阴、清热解毒之品,可为偏头痛的临床治疗与新药开发提供一定参考。Objective To investigate the compatibility regularity of Chinese medicinal compounds for the treat-ment of migraine in the national patent database using data mining techniques and provide insights for the clinical treatment of migraine and the development of new drugs.Methods The patent data for Chinese medicinal compounds used in the treatment of migraine were retrieved from the database of the China National Intellectual Property Administration until May 1,2022.The selected Chinese medicinal compounds were analyzed using data mining techniques,including frequency anal-ysis of drugs,analysis of nature,flavor,and meridian tropism,analysis of therapeutic effects,correlation analysis,cluster a-nalysis,and complex network analysis using the Ancient and Modern Medical Case Cloud Platform(V2.3.5).Results Through retrieval and screening,394 eligible Chinese medicinal compounds were included,involving 667 drugs,with a total drug frequency of 4737.The top 10 most frequently used drugs were Chuanxiong Rhizoma,Angelicae Dahuricae Radix,Gastrodiae Rhizoma,Glycyrrhizae Radix et Rhizoma,Angelicae Sinensis Radix,Paeoniae Radix Alba,Saposhnikoviae Ra-dix,Asari Radix et Rhizoma,Chrysanthemi Flos,and Bupleuri Radix.In terms of nature,flavor,and meridian tropism,the majority of drugs were warm,followed by plain and slightly cold,and pungent,followed by sweet and bitter.The drugs pri-marily acted on the liver meridian,followed by the lung,spleen,heart,stomach,and kidney meridians.In terms of efficacy,drugs mainly had wind-dispelling and pain-relieving,heat-clearing and toxin-removing,exterior-releasing and cold-dispersing,liver-yang suppressing,and blood-activating and qi-moving effects.The frequently associated drug com-binations included Chuanxiong Rhizoma-Angelicae Dahuricae Radix,Gastrodiae Rhizoma-Chuanxiong Rhizoma,Angeli-cae Sinensis Radix-Chuanxiong Rhizoma,Asari Radix et Rhizoma-Chuanxiong Rhizoma,Gastrodiae Rhizoma-Angelicae Dahuricae Radix,and Asari Radix et Rhizoma-Angelicae Dahuricae Radix.Cluster analysis grouped 27

关 键 词：偏头痛 数据挖掘 用药规律 中药复方专利 

分 类 号：R747.2[医药卫生—神经病学与精神病学]