DNA甲基化预测宫颈癌及癌前病变的研究进展  

Research Progress on DNA Methylation in Predicting Cervical Cancer and Precancerous Lesions

作　　者：吴若兰 邱丽华(审校)[1] WU Ruo-Lan;QIU Li-hua(Department of Obstetrics and Gynecology,Shanghai Key Laboratory of Gynecologic Oncology,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院妇产科,上海市妇科肿瘤重点实验室,200127

出　　处：《国际妇产科学杂志》2023年第3期281-285,共5页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(82072865)

摘　　要：近年来随着早期筛查的普及,我国的宫颈癌发病率及死亡率均有所下降,细胞学检查及高危型人乳头瘤病毒(human papilloma virus,HPV)检测是目前常用的宫颈癌筛查手段,但二者均有局限性,细胞学检查可能导致疾病漏诊,而高危型HPV检测常导致过度诊疗,因此,探索一种新的宫颈癌筛查或分流手段十分必要。DNA甲基化是一种常见的表观遗传方式,随着DNA甲基化检测技术的发展,其在肿瘤诊疗领域发挥越来越大的作用。近年来发现许多甲基化基因可作为宫颈癌标志物,在宫颈癌筛查及分流方面具有应用前景,并且具有预测疾病转归、采样方便等优势,有利于宫颈癌的早期诊断及治疗。综述DNA甲基化在宫颈癌及宫颈癌前病变中的相关研究进展。In recent years,with the popularization of early screening,the incidence and mortality rate of cervical cancer in China have decreased.Cytological examination and high-risk human papilloma virus(HPV)test are common screening methods for cervical cancer at present,but they both have their limitations.Cytological examination may lead to missed diagnosis,while high-risk HPV test may lead to over-diagnosis and over-treatment.Therefore,it is necessary to explore a new screening or triage method for cervical cancer.DNA methylation is a common epigenetic modality.With the development of DNA methylation detection technology,DNA methylation has played an increasingly important role in the field of oncology diagnosis and treatment.In recent years,a large amount of DNA methylation genes has been found as markers of cervical cancer,which have a promising application in cervical cancer screening and triage,and have the advantages of prognosis prediction and convenient sampling.DNA methylation is beneficial for the early diagnosis and treatment of cervical cancer.This article reviews the research progress of DNA methylation in cervical cancer and precancerous lesions.

关 键 词：DNA甲基化 宫颈肿瘤 癌前状态 癌症早期检测 乳头状瘤病毒科 

分 类 号：R737.33[医药卫生—肿瘤]