难治性癫痫的外科诊疗进展  

Progress in Surgical Diagnosis and Treatment of Drug-resistant Epilepsy

作　　者：张洋铭 魏怡名 唐振刚[3] ZHANG Yang-ming;WEI Yi-ming;TANG Zhen-gang(Hubei University of Medicine,Hubei Shiyan 442000,China;Jinzhou Medical University,Liaoning Jinzhou 121001,China;Department of Neurosurgery,Shiyan People’s Hospital affiliated to Hubei University of Medicine,Hubei Shiyan 442099,China)

机构地区：[1]湖北医药学院,湖北十堰442000 [2]锦州医科大学,辽宁锦州121001 [3]湖北医药学院附属十堰市人民医院神经外科,湖北十堰442099

出　　处：《神经损伤与功能重建》2023年第6期346-348,372,共4页Neural Injury and Functional Reconstruction

摘　　要：癫痫是由各种原因引起的脑神经元高度同步化异常放电所致的临床综合征,其患病率为0.8%~1.2%。30%~40%的癫痫患者呈药物难治性(规律使用一线抗癫痫药物2年仍不能充分控制癫痫发作),其中10%~50%该类患者可以选择癫痫手术治疗。癫痫手术旨在通过切除致痫灶控制癫痫发作,同时通过保留重要的大脑功能区域以避免神经心理和功能出现障碍。本文就难治性癫痫外科手术过程中的术前评估、致痫灶定位、手术方式的选择及手术预后等几个方面综述如下。Epilepsy is a clinical syndrome caused by highly synchronous abnormal discharge of neurons in the brain,which is caused by a variety of reasons.With a prevalence of 0.8%to 1.2%,epilepsy represents one of the most frequent chronic neurological disorders.30%to 40%of patients suffer from drug-resistant epilepsy(regu-lar use of first-line antiepileptic drugs for 2 years still cannot adequately control seizures).Epilepsy surgery rep-resents a valuable treatment option for 10%to 50%of these patients.Epilepsy surgery aims to control seizures by resection of the epileptogenic tissue while avoiding neuropsychological and functional disorders by sparing essential brain areas.In this paper,the preoperative evaluation,location of epileptogenic focus,choice of opera-tive mode and prognosis of refractory epilepsy surgery are summarized.

关 键 词：癫痫 外科治疗 术前评估 定位 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学] R742R651.1