小胶质细胞在多种实验性癫痫发作模型中发挥有益作用  

Microglia Play Beneficial Roles in Multiple Experimental Seizure Models

作　　者：Synphane Gibbs-Shelton Jordan Benderoth Ronald P Gaykema Justyna Straub Kenneth A Okojie Joseph O Uweru Dennis H Lentferink Binita Rajbanshi Maureen N Cowan Brij Patel Anthony Brayan Campos-Salazar Edward Perez-Reyes Ukpong B Eyo 杜一星(编译) 

机构地区：[1]Brain Immunology and Glia Center,University of Virginia,Charlottesville,Virginia,USA [2]Department of Pharmacology,University of Virginia,Charlottesville,Virginia,USA [3]Department of Neuroscience,University of Virginia,Charlottesville,Virginia,USA [4]Neuroscience Graduate Program,University of Virginia,Charlottesville,Virginia,USA [5]不详

出　　处：《神经损伤与功能重建》2023年第6期F0003-F0003,共1页Neural Injury and Functional Reconstruction

摘　　要：癫痫发病率高,影响各年龄层次,包括年轻人和老年人。目前临床上使用的抗癫痫药物都是根据已知的以神经元为中心的机制研发,但有约1/3的患者对现有药物的治疗无效。因此,有必要对癫痫产生和持续的其他替代和补充机制进行研究。神经炎症,广义上定义为中枢神经系统中免疫细胞和分子的激活。研究发现,神经炎症促进癫痫的发生,但参与该病理生理过程的特定细胞尚不清楚。小胶质细胞是大脑的主要炎症细胞。因为既往研究使用的方法对小胶质细胞的特异性较低,或者存在固有的混淆,所以小胶质细胞的作用一直存在争议。使用一种选择性靶向小胶质细胞的方法(以避免上述副作用),我们发现了小胶质细胞在限制化学惊厥、电性和高热性癫痫发作方面有广泛有益作用,并进一步发现小胶质细胞对控制癫痫发作的作用。Seizure disorders are common,affecting both the young and the old.Currently available antiseizure drugs are ineffective in a third of patients and have been developed with a focus on known neurocentric mecha-nisms,raising the need for investigations into alternative and complementary mechanisms that contribute to sei-zure generation or its containment.Neuroinflammation,broadly defined as the activation of immune cells and molecules in the central nervous system(CNS),has been proposed to facilitate seizure generation,although the specific cells involved in these processes remain inadequately understood.The role of microglia,the primary in-flammation-competent cells of the brain,is debated since previous studies were conducted using approaches that were less specific to microglia or had inherent confounds.Using a selective approach to target microglia without such side effects,we show a broadly beneficial role for microglia in limiting chemoconvulsive,electrical,and hy-perthermic seizures and argue for a further understanding of microglial contributions to contain seizures.

关 键 词：CSF1R PLX3397 炎症 小胶质细胞 癫痫发作 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]