Hypomagnesaemia associated with long-term use of proton pump inhibitors  

作　　者：James Wei Tatt Toh Evonne Ong Robert Wilson 

机构地区：[1]General Surgery,Liverpool Hospital,University of New South Wales,Liverpool,New South Wales,Australia [2]University of New South Wales Clinical School,Liverpool,New South Wales,Australia [3]Upper Gastrointestinal Surgery,Liverpool Hospital,University of New South Wales,Liverpool,New South Wales,Australia

出　　处：《Gastroenterology Report》2015年第3期243-253,共11页胃肠病学报道（英文）

摘　　要：Hypomagnesaemia and associated hypocalcaemia and hypoparathyroidism have been increasingly recognised as rare longterm side-effects of proton pump inhibitors(PPIs).The PPIs may inhibit active magnesium(Mg)absorption by interfering with transcellular transient receptor potential melastatin-6 and-7(TRPM 6 and 7)channels.More recent cell culture studies have suggested concomitant inhibition of passive Mg absorption by omeprazole.After being treated with a range of PPIs,the four patients in our case series developed hypomagnesaemia,which responded to withdrawal of therapy and initiation of Mg replacement.Their clinical course and management demonstrate key aspects of hypomagnesaemia associated with long-term use of PPIs.

关 键 词：Proton pump inhibitors HYPOMAGNESAEMIA hypocalcaemia. 

分 类 号：R57[医药卫生—消化系统]