Hyperbaric oxygen therapy for chronic antibioticrefractory ischemic pouchitis  

高压氧治疗慢性抗生素难治性缺血性储袋炎

作　　者：Custon T.Nyabanga Geeta Kulkarni Bo Shen 

机构地区：[1]Cleveland Clinic Lerner College of Medicine of Case Western Reserve University,Cleveland,OH,USA [2]Department of Gastroenterology/Hepatology,Cleveland Clinic,Cleveland,OH,USA

出　　处：《Gastroenterology Report》2017年第4期320-321,I0003,共3页胃肠病学报道（英文）

摘　　要：Hyperbaric oxygen therapy(HBOT)has been shown to be efficacious in treating various conditions,including perianal Crohn’s disease.Here we present a case of a 59-year-old male with a history of ulcerative colitis,who underwent a total proctocolectomy and two-stage J-pouch construction.He later developed chronic antibiotic-refractory pouchitis with endoscopic features of ischemia.At the completion of HOBT-a total of 20 sessions of 100%oxygen at 2.5-3.0 atmospheres absolute for 60-90 minutes per session-a repeat pouchoscopy showed marked improvement of endoscopic mucosal inflammation.HBOT is known to increase tissue oxygenation,reduce tissue hypoxia,alter inflammatory pathways and promote tissue healing.This case demonstrated the therapeutic role of HBOT as well as the possible disease mechanism in chronic antibiotic-refractory pouchitis.

关 键 词：hyperbaric oxygen therapy refractory pouchitis ischemic pouchitis 

分 类 号：R57[医药卫生—消化系统]