结直肠癌进展相关关键分子事件研究进展  

Research Progress of Key Molecular Events Related to Progression of Colorectal Cancer

作　　者：周雄 胡明 蒋栋铭 曹广文 谭晓㛃 ZHOU Xiong;HU Ming;JIANG Dongming;CAO Guangwen;TAN Xiaojie(Department of Epidemiology,Faculty of Naval Medicine,Naval Medical University,Shanghai 200433,China;Shanghai Key Laboratory of Medical Bioprotection,Shanghai 200433,China;Key Laboratory of Biological Defense,Ministry of Education,Shanghai 200433,China;Tongji University School of Medicine,Shanghai 200092,China)

机构地区：[1]海军军医大学海军医学系流行病学教研室,上海200433 [2]上海市医学生物防护重点实验室,上海200433 [3]生物安全防御教育部重点实验室,上海200433 [4]同济大学医学院,上海200092

出　　处：《肿瘤防治研究》2023年第6期609-615,共7页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81672518);上海市“公共卫生体系建设三年行动计划”(GWV-10.1-XK17)。

摘　　要：随着高通量及单细胞测序技术的不断发展,到空间转录组测序的出现,结直肠癌进展中时间和空间上的分子事件不断被发现,这使我们更好理解结直肠癌恶性进展的机制。从基因组学层面的遗传变异(如APC和P53等基因突变)、DNA错配修复(dMMR)等,到转录后调控水平如表观遗传改变等,再到出现复杂的分子网络的动态改变,每一步都有特异的分子发挥关键作用。CRC进展后期出现的耐药、转移等与这些关键分子事件密不可分。本文通过综述CRC中的分子事件研究进展,探索CRC恶性进展的关键分子事件,由此为探索更深层次CRC调控机制、预后预测和治疗提供科学依据和思路。The continuous development of high-throughput and single-cell sequencing technologies and the emergence of spatial transcriptome sequencing have allowed the continuous discovery of temporal and spatial molecular events in the progression of colorectal cancer(CRC)to better understand its mechanism of malignant progression.Genetic variations(mutation of APC and P53,etc.)and mismatch repair of DNA,posttranscriptional regulation,such as epigenetic alteration,and dynamic alteration of complex molecular networks have their own special molecules that play key roles.Drug resistance and metastasis in the late stage of CRC progression are closely related to these key molecular events.This article reviews the research progress and explores key molecular events in the malignant progression of CRC to provide scientific basis and ideas for elucidating the regulatory mechanism of CRC and evaluating its prognosis prediction and treatment.

关 键 词：结直肠癌 恶性进展 遗传变异 分子事件 

分 类 号：R735.3[医药卫生—肿瘤]