C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut  

C型凝集素受体介导的对肠道微生物的免疫识别和免疫反应

作　　者：Tian-Hang Li Ling Liu Ya-Yi Hou Su-Nan Shen Ting-Ting Wang 

机构地区：[1]Immunology and Reproduction Biology Lab,Medical School of Nanjing University,State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing,Jiangsu,P.R.China [2]Jiangsu Key Laboratory of Molecular Medicine,Nanjing University,Nanjing,Jiangsu,P.R.China

出　　处：《Gastroenterology Report》2019年第5期312-321,I0001,共11页胃肠病学报道（英文）

基　　金：This work is supported by grants from the National Natural Science Foundation of China(81572354 and 81772542 to T.W.);the Natural Science Foundation of Jiangsu Province in China(BK20161400 to T.W.).

摘　　要：C-type lectin receptors(CLRs)are powerful pattern-recognition receptors that discern‘self’and‘non-self’in our body and protect us from invasive pathogens by mediating immune recognition and response.The gastrointestinal tract is very important for the maintenance of homeostasis;it is the largest shelter for the billions of microorganisms in the body and CLRs play a crucial regulatory role in this system.This study focuses on several CLRs,including Dectin-1,Dectin-2,Dectin-3 and Mincle.We summarize the roles of CLRs in maintaining gastrointestinal immune-system homeostasis,especially their functions in mediating immune recognition and responses in the gut,discuss their relationships to some diseases,highlight the significance of CLR-mediated sensing of microbial and non-microbial compounds in the gut immune system and identify new therapeutic targets.C型凝集素受体(CLRs)是一种功能强大的模式识别受体,能识别我们体内的“自体”与“非自体”,并通过调节免疫识别和免疫应答来保护我们免受外源性病原体的侵害。胃肠道对维持人体稳态非常重要,它是体内数十亿微生物的最大栖息地,而CLRs在这个系统中发挥着至关重要的调节作用。本文聚焦于包括Dectin-1、Dectin-2、Dectin-3和Mincle在内的数种CLRs。我们总结了CLRs在维持胃肠道免疫系统稳态中的作用,特别是在肠道中介导免疫识别与免疫应答的功能;讨论了CLRs与某些疾病的相关性,着重论述了CLR介导的对微生物与非微生物复合体的识别感应在肠道免疫系统中的重要性,并据此提出了一些新的治疗靶点。

关 键 词：C-type lectin receptors(CLRs) MICROBIOTA IMMUNITY inflammatory bowel disease(IBD) 

分 类 号：R333.3[医药卫生—人体生理学]