2-芳基丙烷-1,3-二亚甲基双异吲哚-1-酮的合成  

Synthesis of(2-Arylpropane-1,3-diylidene)bis(isoindolin-1-ones)

作　　者：陈依华 龙燕 张霞 卜发洋 张晓梅 CHEN Yihua;LONG Yan;ZHANG Xia;BU Fayang;ZHANG Xiaomei(Department of Chemistry,Xihua University,Chengdu 610039,China;Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China)

机构地区：[1]西华大学化学系,四川成都610039 [2]中国科学院成都有机化学研究所,四川成都610041

出　　处：《合成化学》2023年第6期453-463,共11页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21672208)。

摘　　要：异吲哚啉酮具有广泛的生物活性,合成结构多样的新型异吲哚啉-1-酮类化合物具有重要意义。为构建新型异吲哚啉-1-酮类化合物,以3-亚甲基异吲哚啉-1-酮和芳香醛为原料,在三氯硅烷作用下发生缩合反应,以普遍中等到良好的产率得到一系列2-芳基丙烷-1,3-二亚甲基双异吲哚-1-酮类化合物,所有产物结构由^(1)H NMR,^(13)C NMR和HR-MS(ESI)确证,另外还得到了产物3aa的单晶,通过X-射线衍射确定其构型为(3 E,3′E)。Isoindolinones have a wide variety of bioactivities.Synthesis of novel isoindolinones is of great importance.In order to construct new isoindolinones,in the presence of trichlorosilane,condensation of 3-methyleneisoindoline-1-ones with aryl aldehydes has been realized.A wide variety of(2-arylpropane-1,3-diylidene)bis(isoindolin-1-ones)were prepared in generally moderate to good yields.The structures of all products were confirmed by ^(1)H NMR,^(13)C NMR and HR-MS(ESI).Moreover,the configuration of one product was determined as(3 E,3′E)by a X-ray crystal analysis.

关 键 词：3-亚甲基异吲哚啉-1-酮 芳香醛 缩合反应 三氯硅烷 2-芳基丙烷-1 3-二亚甲基双异吲哚-1-酮 单晶X-射线衍射 结构确证 

分 类 号：O626.29[理学—有机化学]