奥卡西平治疗部分性发作癫痫患者的效果观察  

Effect Observation of Oxcarbazepine in Treatment of Patients with Partial Epilepsy Seizure

作　　者：赵云宇 Zhao Yunyu(Daqing City Longnan Hospital,Daqing 163000,Heilongjiang Province,China)

机构地区：[1]黑龙江省大庆市龙南医院,黑龙江大庆163000

出　　处：《中国社区医师》2023年第14期40-42,共3页Chinese Community Doctors

摘　　要：目的:分析奥卡西平治疗部分性发作癫痫患者的效果。方法:选取2020年1月—2021年6月黑龙江省大庆市龙南医院收治的86例部分性发作癫痫患者作为研究对象,以随机数字表法分为观察组与对照组,各43例。观察组采用奥卡西平治疗,对照组采用卡马西平治疗,比较两组治疗效果、认知功能、脑电图情况、不良反应发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.016)。治疗前,两组韦氏成人智力量表中的全量表智商(FIO)、操作智商(PIQ)和语言智商(VIQ)评分比较,差异无统计学意义(P>0.05);治疗后,观察组FIO、PIQ、VIQ评分均高于对照组,差异有统计学意义(P<0.05)。观察组脑电图正常、显著好转占比高于对照组,无变化、恶化占比低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:奥卡西平治疗部分性发作癫痫患者的效果较好,可改善脑电图情况,提升认知功能,且安全性良好,值得应用并予以推广。Objective:To analyze the effect of oxcarbazepine in the treatment of patients with partial epilepsy seizure.Methods:From January 2020 to June 2021,86 patients with partial epilepsy seizure in Daqing City Longnan Hospital of Heilongjiang Province were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 43 cases in each group.The observation group was treated with oxcarbazepine,and the control group was treated with carbamazepine.The treatment effect,cognitive function,EEG and adverse reactions in the two groups were compared.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.016).Before treatment,there was no significant difference in the scores of full scale intelligence quotient(FIO),performance intelligence quotient(PIQ)and verbal intelligence quotient(VIQ)in the Wechsler Adult Intelligence Scale between two groups(P>0.05).After treatment,the FIO,PIQ and VIQ scores in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The proportion of normal EEG and significant improvement in the observation group was higher than that in the control group,and the proportion of no change and deterioration in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Oxcarbazepine has a good effect in the treatment of patients with partial epilepsy seizure,it can improve EEG and enhance cognitive function with good safety.It is worthy of application and promotion.

关 键 词：部分性发作癫痫 奥卡西平 脑电图 

分 类 号：R742.1[医药卫生—神经病学与精神病学]