宫颈癌人群人乳头状瘤病毒型别分布  

Distribution of human papillomavirus types in cervical cancer population

作　　者：王希 蒋慧云[1] 李小毛[1] Wang Xi;Jiang Huiyun;Li Xiaomao(Department of Gynecology,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院妇科,广州510630

出　　处：《中国医师杂志》2023年第5期666-669,共4页Journal of Chinese Physician

基　　金：广东省自然科学基金(2021A1515011542)。

摘　　要：目的探讨宫颈浸润癌人群中感染人乳头状瘤病毒(HPV)型别分布。方法回顾性选取2016年1月至2020年12月在中山大学附属第三医院经病理诊断为宫颈浸润癌且相关资料齐全的住院患者,记录诊断宫颈癌时的年龄、组织学分类、感染HPV具体型别,并对鳞癌及腺癌人群中HPV型别差异及单一和多重感染情况进行分析。分析双价、四价、九价HPV疫苗涵盖型别感染在宫颈癌人群的覆盖率。结果纳入符合标准的宫颈浸润癌231例,其中鳞癌183例,腺癌43例,另有其他组织学类型5例。宫颈癌、鳞癌与腺癌人群HPV感染阳性率分别为89.18%(206/231)、92.35%(169/183)、74.42%(32/43)。宫颈癌患者HPV感染前五位的型别依次为16、18、58、52、31和33;鳞癌患者感染率前五位的型别依次为HPV16、18、58、52、31和33;腺癌患者仅检测出5种HPV型别,主要型别为HPV16、18。宫颈癌、鳞癌、腺癌患者单一HPV型别感染率分别为77.49%(179/231)、79.23%(145/183)、67.44%(29/43),多重感染率分别为11.69%(27/231)、13.11%(24/183)、6.98%(3/43)。宫颈癌各年龄段人群HPV阳性率均较高。双价、四价、九价HPV疫苗涵盖型别感染在宫颈癌人群的覆盖率分别为66.67%~74.03%、67.53%~74.89%、81.39%~87.44%。结论宫颈癌人群以高危型HPV单一感染为主,主要包括HPV16、18、58、52、31、33;鳞癌人群中HPV感染率高于腺癌组,主要型别为HPV16,腺癌人群中主要型别是HPV16、18。Objective To investigate the distribution of human papillomavirus(HPV)subtypes in patients with cervical invasive cancer.Methods Retrospective selection was conducted on hospitalized patients diagnosed with cervical invasive cancer by pathology at the Third Affiliated Hospital of Sun Yat-sen University from January 2016 to December 2020,with complete relevant information.The age,histological classification,specific HPV infection types at the time of diagnosis of cervical cancer were recorded,and differences in HPV types and single and multiple infections in the squamous cell carcinoma and adenocarcinoma populations were analyzed.The coverage rate of bivalent,tetravalent,and ninvalent HPV vaccines in the cervical cancer population was analyzed.Results A total of 231 cases of cervical invasive cancer that met the criteria were included,including 183 cases of squamous cell carcinoma,43 cases of adenocarcinoma,and 5 cases of other histological types.The positive rates of HPV infection in cervical cancer,squamous cell carcinoma,and adenocarcinoma populations were 89.18%(206/231),92.35%(169/183),and 74.42%(32/43),respectively.The top five types of HPV infection in cervical cancer patients were 16,18,58,52,31,and 33,respectively;The top five types of infection rate in squamous cell carcinoma patients were HPV16,18,58,52,31,and 33,respectively;Adenocarcinoma patients only detected 5 types of HPV,with the main types being HPV16 and 18.The infection rates of single HPV type in patients with cervical cancer,squamous cell carcinoma,and adenocarcinoma were 77.49%(179/231),79.23%(145/183),and 67.44%(29/43),respectively.The multiple infection rates were 11.69%(27/231),13.11%(24/183),and 6.98%(3/43),respectively.The positive rate of HPV was higher in all age groups of cervical cancer.The coverage rates of bivalent,tetravalent,and ninvalent HPV vaccines covering different types of infections in cervical cancer populations were 66.67%to 74.03%,67.53%to 74.89%,and 81.39%to 87.44%,respectively.Conclusions The cervical cancer populat

关 键 词：宫颈肿瘤 人乳头状瘤病毒 

分 类 号：R737.33[医药卫生—肿瘤]