基于“肾脑相关”理论探讨五子衍宗丸联合针刺对肾精亏虚证血管性痴呆患者氧化应激水平及认知功能的影响  

Exploring Effect of Wuzi Yanzong Pill(五子衍宗丸)Combined with Acupuncture on Oxidative Stress Level and Cognitive Function of Vascular Dementia Patients with Kidney Essence Deficiency Syndrome Based on Theory of“Kidney-Brain Correlation”

作　　者：梁雪松[1] LIANG Xuesong(Shenyang Seventh People′s Hospital,Shenyang 110003,Liaoning,China)

机构地区：[1]沈阳市第七人民医院,辽宁沈阳110003

出　　处：《辽宁中医杂志》2023年第5期85-89,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)项目(2013CB532004);辽宁省科技厅重大项目(20231030021/10300021);辽宁省教育厅科研项目(L202033)。

摘　　要：目的针对基于“肾脑相关”理论探讨五子衍宗丸联合针刺对肾精亏虚证血管性痴呆患者氧化应激水平及认知功能的影响开展深入分析,探讨五子衍宗丸联合针刺治疗在临床上的价值。方法选取该院2019年12月-2021年6月收治的肾精亏虚证血管性痴呆患者100例设为研究对象,遵从“乱数表法”分配原则,将参与研究的肾精亏虚证血管性痴呆患者分配到对照组和研究组,两组比例1∶1。研究组50例,给予五子衍宗丸联合针刺治疗;对照组50例,给予常规治疗。分析两组患者治疗前后的中医症状评分、氧化应激水平、认知功能以及血液指数变化。结果治疗后,对照组的中医症状评分高于研究组,组间差异具有统计学意义(P<0.05);对照组的氧化应激水平相关参数均高于研究组,组间差异具有统计学意义(P<0.05);对照组的痴呆简易筛查量表评分高于研究组,组间差异具有统计学意义(P<0.05);对照组的简易精神状态低于研究组,组间差异具有统计学意义(P<0.05);对照组的各组血液指数水平均高于研究组,组间差异具有统计学意义(P<0.05);研究组患者临床疗效高于对照组,组间差异具有统计学意义(P<0.05)。结论肾精亏虚证血管性痴呆患者行五子衍宗丸联合针刺治疗取得了更为理想临床结局,此治疗方式适用于肾精亏虚证血管性痴呆患者的临床推广,可以提高五子衍宗丸联合针刺治疗的临床价值,对患者有着重要意义。Objective To explore the effect of Wuzi Yanzong Pill(五子衍宗丸)combined with acupuncture on oxidative stress level and cognitive function in vascular dementia patients with kidney essence deficiency syndrome based on the theory of“kidney-brain correlation”and explore the clinical application value of Wuzi Yanzong Pill combined with acupuncture.Methods A total of 100 vascular dementia patients with kidney essence deficiency syndrome who admitted to the hospital from December 2019 to June 2021 were enrolled as the research object.The patients were randomly divided into study group and control group with a ratio of 1∶1 according to the distribution principle of“random number table method”.Fifty cases in the study group were treated with Wuzi Yanzong Pill combined with acupuncture and the other 50 cases in the control group were given routine treatment.The changes of TCM symptom score,oxidative stress level,cognitive function and blood parameters were analyzed before and after treatment.Results After treatment,the score of TCM symptoms in the control group was higher than that in the study group,and the difference between the groups was statistically significant(P<0.05).The level of oxidative stress and related parameters in the control group were higher than those in the study group,and the difference between the two groups was statistically significant(P<0.05).The score of dementia simple screening scale in the control group was higher than that in the study group,and the difference between the groups was statistically significant(P<0.05).The simple mental state of the control group was lower than that of the study group and the difference between the two groups was statistically significant(P<0.05).The levels of blood parameters in the control group were higher than those in the study group,and the difference between the two groups was statistically significant(P<0.05).The clinical efficacy of the study group was higher than that of the control group and the difference between the two groups was st

关 键 词：五子衍宗丸 针刺 氧化应激水平 认知功能 肾精亏虚证 血管性痴呆 

分 类 号：R749.16[医药卫生—神经病学与精神病学]