^(18)F-FDG PET/CT显像肿瘤代谢体积和病灶糖酵解总量对广泛期小细胞肺癌预后的预测价值  

Predictive value of metabolic tumor volume and total lesion glycolysis in ^(18)F-FDG PET/CT imaging for prognosis in patients with extensive-stage small cell lung cancer

作　　者：陈平 王庆祝[1] 刘保平[1] 杜彪[1] 谢新立[1] 王瑞华[1] 王心宇 Chen Ping;Wang Qingzhu;Liu Baoping;Du Biao;Xie Xinli;Wang Ruihua;Wang Xinyu(Department of Nuclear Medicine,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院核医学科,郑州450052

出　　处：《中华核医学与分子影像杂志》2023年第5期263-266,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：目的探讨18F-FDG PET/CT显像中肿瘤代谢体积(MTV)和病灶糖酵解总量(TLG)对广泛期小细胞肺癌(ES-SCLC)预后的预测价值。方法回顾性分析2019年3月至2020年6月期间在郑州大学第一附属医院于治疗前行18F-FDG PET/CT显像的ES-SCLC患者69例(男55例、女14例,年龄38~87岁),收集患者的临床特征及18F-FDG PET/CT代谢参数,包括性别、年龄、吸烟史、是否体质量减轻、肝转移、骨转移、恶性积液、原发灶SUVmax、全身MTV之和(wbMTV)及全身TLG之和(wbTLG),分别以40%SUVmax、SUV=2.5为阈值计算得到wbMTV40%、wbTLG40%、wbMTV2.5、wbTLG2.5;随访患者总生存(OS)。采用Kaplan-Meier法分析OS预后因素。结果69例ES-SCLC患者中,死亡43例(62%),存活26例(38%),中位生存时间15.0(95%CI:11.7~18.3)个月。单因素分析显示,年龄(χ^(2)=4.53,P=0.033)、骨转移(χ^(2)=18.05,P<0.001)、肝转移(χ^(2)=27.94,P<0.001)、wbMTV2.5(χ^(2)=3.98,P=0.046)、wbTLG2.5(χ^(2)=5.80,P=0.016)是影响OS的预后因素。结论wbMTV2.5和wbTLG2.5与ES-SCLC患者OS有关,对预测ES-SCLC患者的预后具有一定的参考价值。Objective To investigate the prognostic value of metabolic tumor volume(MTV)and total lesion glycolysis(TLG)in patients with extensive-stage small cell lung cancer(ES-SCLC).Methods From March 2019 to June 2020,69 patients(55 males,14 females,age:38-87 years)with ES-SCLC who underwent pretreatment ^(18)F-FDG PET/CT in First Affiliated Hospital of Zhengzhou University were retrospectively enrolled.The variables including gender,age,smoking,weight loss,liver metastasis,bone metastasis,malignant effusion,SUVmax of the primary tumor,whole-body MTV(wbMTV)and whole-body TLG(wbTLG)(including wbMTV40%,wbTLG40%,wbMTV2.5 and wbTLG2.5)were analyzed.The predictors of overall survival(OS)were analyzed by using Kaplan-Meier method(log-rank test).Results Of 69 ES-SCLC patients,43(62%)died and 26(38%)were still alive by the end of follow-up,with a median survival time of 15.0(95%CI:11.7-18.3)months.Univariate analysis revealed that age(χ^(2)=4.53,P=0.033),bone metastasis(χ^(2)=18.05,P<0.001),liver metastasis(χ^(2)=27.94,P<0.001),wbMTV2.5(χ^(2)=3.98,P=0.046),and wbTLG2.5(χ^(2)=5.80,P=0.016)were significant predictors of OS.Conclusion wbMTV2.5 and wbTLG2.5 are assosciated with OS and may provide some reference value for predicting the prognosis of ES-SCLC patients.

关 键 词：小细胞肺癌 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 预后 预测 

分 类 号：R734.2[医药卫生—肿瘤]