双环醇联合异甘草酸镁对BHV感染失代偿期肝硬化患者临床疗效及对肝功能、血清炎性因子、Toll样受体4和谷草转氨酶-血小板比值指数的影响  

CLINICAL EFFICACY OF BICYCLOL COMBINED WITH MAGNESIUM ISOGLYCYRRHIZINATE IN PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS DUE TO BHV INFECTION AND ITS EFFECTS ON LIVER FUNCTION,SERUM INFLAMMATORY FACTORS,TOLL LIKE RECEPTOR 4 AND GLUTAMIC OXALOACETIC TRANSAMINASE PLATELET RATIO INDEX

作　　者：梅冬雪 张国顺 杨学慧 辛英瑛 石峥 王素颖 汪海涛[3] 夏建新 杨艳英 MEI Dongxue;ZHANG Guoshun;YANG Xue-hui;XIN Yingying;SHI Zheng;WANG Suying;WANG Haitao;XIA Jianxin;YANG Yanying(Department of Gastroenterology,Affiliated Hospital of North China University of Science and Technology Tangshan 063000,China)

机构地区：[1]华北理工大学附属医院消化内科,河北省唐山市063000 [2]华北理工大学附属医院血液内科 [3]开滦总医院消化内科

出　　处：《中国煤炭工业医学杂志》2023年第2期209-214,共6页Chinese Journal of Coal Industry Medicine

基　　金：河北省医学科学研究重点课题计划项目(编号:20170933);河北省科技厅资助项目(编号:162777133)。

摘　　要：目的探讨双环醇联合异甘草酸镁对HBV感染失代偿期肝硬化患者肝功能、血清炎性因子、Toll样受体4及对谷草转氨酶-血小板比值指数的影响。方法选取2019年1月—2021年12月华北理工大学附属医院和开滦总医院住院的HBV感染失代偿期肝硬化患者134例患者,按照随机数字表法分为随机分为对照组和观察组,每组各67例。对照组给予异甘草酸镁治疗,观察组给予异甘草酸镁和双环醇治疗。观察所有患者肝肾功能、血清炎性因子、Toll样受体4及对谷草转氨酶-血小板比值指数的变化。结果治疗后ALT、AST、ALP、TBIL、HA、LN、PCIII、CIV、BUN、Cr、阻力指数、IL-6、IL-8、TNF-α、CRP、TLR-4、TGF-β1、APRI水平较治疗前降低,ALB、肾血流量较治疗前升高;差异均有统计学意义。观察组肝肾功能、肝纤维化指标、肝影像学指标、血清炎症因子改善情况优于对照组,差异均有统计学意义。观察组总有效率高于对照组(97.01%vs 86.57%),差异有统计学意义。结论双环醇联合异甘草酸镁对BHV感染失代偿期肝硬化患者临床疗效显著,可以改善肝肾功能,降低炎症反应,改善谷草转氨酶-血小板比值指数,安全性较好。Objective To investigate the effects of bicyclol combined with magnesium isoglycyrrhizinate on liver function, serum inflammatory factors, Toll like receptor 4 and the ratio index of glutamic oxaloacetic transaminase to platelet in patients with decompensated hepatitis B cirrhosis. Methods One hundred and thirty-four patients with decompensated liver cirrhosis due to BHV infection hospitalized in the Affiliated Hospital of North China University of Technology and Kailuan General Hospital from January 2019 to December 2021 were selected and randomly divided into the control group and the case group according to the random number table, with 67 patients in each group.The control group was treated with magnesium isoglycyrrhizinate, and the case group was treated with magnesium isoglycyrrhizinate and bicyclic alcohol.To observe the changes of liver and kidney functions, serum inflammatory factors, Toll like receptor 4,and the ratio index of glutamic oxaloacetic transaminase to platelet in all patients. Results After treatment, alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total bilirubin(TBIL),hyaluronic acid(HA),laminin(LN),procollagen III(PCIII),collagen IV(CIV),urea nitrogen(BUN),creatinine(Cr),resistance index, serum interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),Toll like receptor 4(TLR-4),transforming growth factor β 1(TGF-β 1) The level of glutamic oxaloacetic transaminase platelet ratio index(APRI) was lower than that before treatment, while albumin(ALB) and renal blood flow were higher than that before treatment;The differences were statistically significant.The improvement of liver and kidney function, liver fibrosis index, liver imaging index and serum inflammatory factors in the case group were better than those in the control group, with statistical significance.The total effective rate of the case group was higher than that of the control group(97.01% vs 86.57%),with a statistically significant difference. Conc

关 键 词：双环醇 异甘草酸镁 失代偿期肝硬化 谷草转氨酶-血小板比值指数 

分 类 号：R575.2[医药卫生—消化系统]