类菌孢素氨基酸生物合成研究进展  

Research progress of the biosynthesis of mycosporine-like amino acids

作　　者：王伟[1] 孙晶晶[1] 郝建华[1] WANG Wei;SUN Jingjing;HAO Jianhua(Key Laboratory of Sustainable Development of Polar Fishery,Ministry of Agriculture and Rural Affairs,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao 266071,China)

机构地区：[1]中国水产科学研究院黄海水产研究所,农业农村部极地渔业可持续利用重点实验室,青岛266071

出　　处：《生命的化学》2023年第4期473-478,共6页Chemistry of Life

基　　金：中国水产科学研究院黄海水产研究所基本科研业务费专项资金项目(20603022021016);中国水产科学研究院基本科研业务费专项资金项目(2020TD67);国家自然科学基金项目(31900035)。

摘　　要：现有的人工合成的防晒剂可能危害环境,而天然的水溶性小分子抗辐射化合物——类菌孢素氨基酸(mycosporine-like amino acids,MAAs)有望成为环境友好型防晒剂,具有广阔的应用前景。从生物体内提取的MAAs产量不足,无法满足商用需求。以合成生物学方法在宿主细胞中表达MAAs合成基因簇是解决MAAs供应不足的有效策略。本文简介MAAs的生物合成途径,总结现有MAAs生物合成研究的成果,分析探讨MAAs生物合成发展方向。The synthetic chemical ultraviolet filters may cause the environmental pollution,while the small natural water-soluble ultraviolet light-absorbing compounds mycosporine-like amino acids(MAAs)are expected to become ecologically friendly sunscreens with broad application prospects.The MAAs content are low in the producing organisms,obstructing MAAs exploitation as safe alternatives to currently used commercial products.Expression of MAAs biosynthetic gene clusters in host cells via synthetic biology is an effective strategy to solve the shortage of MAAs supply.This paper introduces the biosynthetic pathway of MAAs,summarizes the progress of MAAs biosynthesis,and discusses the strategies to improve MAAs biosynthesis efficiency.

关 键 词：类菌孢素氨基酸 合成生物学 异源表达 防晒剂 

分 类 号：TQ658.24[化学工程—精细化工]