不同HER-2表达水平乳腺癌患者新辅助化疗疗效与生存分析  

Analysis of the efficacy and survival outcomes of neoadjuvant chemotherapy in breast cancer patients with different HER-2 expression levels

作　　者：王晓敏 彭璐珊 王潇潇 张倩[1,3] 张航豪 彭帅 廖立秋[1,3] WANG Xiaomin;PENG Lushan;WANG Xiaoxiao;ZHANG Qian;ZHANG Hanghao;PENG Shuai;LIAO Liqiu(Department of Breast Surgery,Xiangya Hospital,Central South University,Changsha 410008,China;Department of Pathology,Xiangya Hospital,Xiangya Hospital,Central South University,Changsha 410008,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院乳腺外科,湖南长沙410008 [2]中南大学湘雅医院病理科,湖南长沙410008 [3]中南大学湘雅医院国家老年疾病临床研究中心,湖南长沙410008

出　　处：《中国普通外科杂志》2023年第5期739-751,共13页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(81974420);湖南省自然科学基金资助项目(2021JJ30041)。

摘　　要：背景与目的:新辅助化疗是早期高危或局部晚期乳腺癌降期保乳和提高整体治愈率重要的治疗策略,新辅助化疗人群的选择和方案的制订依赖于分子分型。然而目前尚缺乏不同人表皮生长因子受体2(HER-2)表达水平的乳腺癌新辅助化疗疗效及生存预后差异的研究。本研究通过比较不同HER-2表达水平的乳腺癌患者新辅助化疗疗效及生存预后的差异,旨在明确其新辅助化疗疗效及生存预后的影响因素,为临床新辅助化疗人群选择和方案制订提供参考。方法:回顾性分析2018年1月—2022年5月于中南大学湘雅医院乳腺外科接受新辅助化疗且行根治性手术的乳腺癌患者资料。比较不同HER-2表达水平(0表达、低表达、过表达)患者临床病理特征的差异,用Logistic回归分析筛选病理完全缓解(pCR)的独立影响因素,用Kaplan-Meier方法估计患者的生存曲线,用Log-rank检验比较生存率的差异,通过Cox回归分析筛选预后的独立影响因素。结果:共纳入601例患者,其中HER-20表达231例(38.4%)、HER-2低表达137例(22.8%)、HER-2过表达233例(38.8%)。与HER-20表达患者和HER-2过表达患者比较,HER-2低表达患者具有更高的BMI,合并肿瘤家族史更少见,组织学分级更低,激素受体(HR)阳性比例更高;HER-2过表达患者的肿瘤纤维化程度明显低于HER-20表达和HER-2低表达患者(均P<0.05)。HER-2低表达患者中,HR阴性亚组患者较HR阳性亚组患者肿块更大,组织学分级更高,Ki-67水平更高(均P<0.05)。全组患者中,HER-2表达水平、pCR、临床淋巴结分期(cN)是患者无病生存(DFS)的独立影响因素(均P<0.05)。HER-2过表达患者的新辅助化疗pCR率及DFS率明显高于HER-2低表达和HER-20表达患者(均P<0.05),但HER-2低表达和HER-20表达患者的新辅助化疗pCR率及DFS率无明显差异(均P>0.05)。肿瘤纤维化程度和雌激素受体(ER)状态是HER-20表达乳腺癌pCR的独立影响因素,间质肿瘤浸�Background and Aims:Neoadjuvant chemotherapy is an important treatment strategy for breast preservation after downstaging and improving overall cure rates in early high-risk or locally advanced breast cancer.The selection of patients and the development of treatment plans for neoadjuvant chemotherapy depend on molecular subtypes.However,there is currently a lack of research on the efficacy of neoadjuvant chemotherapy and differences in survival prognosis based on the expression levels of human epidermal growth factor receptor 2(HER-2)in breast cancer.Therefore,this study was performed to compare the efficacy of neoadjuvant chemotherapy and differences in survival prognosis among breast cancer patients with different levels of HER-2 expression,and identify the factors influencing the efficacy of neoadjuvant chemotherapy and survival prognosis,so as to provide valuable insights for the selection of patients and development of treatment plans for clinical neoadjuvant chemotherapy.Methods:The data of breast cancer patients who underwent neoadjuvant chemotherapy and radiacal mastectomy in the Department of Breast Surgery,Xiangya Hospital,Central South University,from January 2018 to May 2022 were retrospectively analyzed.The differences in clinicopathologic characteristics among patients with different HER-2 expression levels(zero-expression,low-expression,overexpression)were compared.Logistic regression analysis was used to identify independent factors influencing pathological complete response(pCR).Kaplan-Meier method was employed to estimate survival curves,and the Log-rank test was used to compare differences in survival rates.Cox regression analysis was conducted to identify independent prognostic factors.Results:A total of 601 patients were included,among whom 231(38.4%)had HER-2 zero-expression,137(22.8%)had HER-2 low-expression,and 233(38.8%)had HER-2 overexpression.Compared to patients with HER-2 zero-expression and HER-2 overexpression,patients with HER-2 low-expression had higher BMI value,fewer cases of fa

关 键 词：乳腺肿瘤 ErbB受体 肿瘤辅助疗法 无病生存 预后 

分 类 号：R737.9[医药卫生—肿瘤]