复明片联合曲伏前列素对青光眼患者眼压及眼表疾病指数的影响  

Effect of Fuming Tablets Combined with Travoprost on Intraocular Pressure and Ocular Surface Disease Index in Patients with Glaucoma

作　　者：金玲艳[1] 颜管根 Lingyan Jin;Guangen Yan(Department of Ophthalmology,Taizhou Municipal Hospital,Taizhou 318000,China)

机构地区：[1]台州市立医院眼科,台州318000

出　　处：《中华眼视光学与视觉科学杂志》2023年第5期379-383,共5页Chinese Journal Of Optometry Ophthalmology And Visual Science

摘　　要：目的:探讨复明片联合曲伏前列素对青光眼患者眼压及眼表疾病指数的影响。方法:前瞻性队列研究。采取单纯随机抽样法收集2021年1月至2022年1月在台州市立医院眼科收治的原发性开角型青光眼(POAG)患者124例(124眼),按照完全随机数字表法随机分成对照组和观察组。对照组62例(62眼)给予曲伏前列素治疗,观察组62例(62眼)给予复明片联合曲伏前列素治疗,2组均治疗3个月。比较2组患者的症状(如视力模糊、眼胀、视力下降、头痛)缓解时间、眼压、眼表疾病指数(OSDI评分)、泪液指标[超氧化物歧化酶(SOD)、一氧化氮(NO)、丙二醛(MDA)]、临床疗效以及不良反应(干眼、眼睑红斑、眼充血、眼部瘙痒)。采用χ^(2)检验和t检验对数据进行统计分析。结果:观察组视力模糊、眼胀、视力下降、头痛的缓解时间均短于对照组(t=7.79~16.36,均P<0.001);观察组治疗后的眼压低于对照组(t=13.56,P<0.001);观察组治疗后的OSDI评分低于对照组(t=19.01,P<0.001);观察组治疗后的SOD水平高于对照组(t=13.11,P<0.001),NO、MDA水平低于对照组(t=7.30、9.26,均P<0.001)。观察组总有效率为97%,高于对照组的84%(χ^(2)=5.91,P=0.015);观察组不良反应发生率为8%,与对照组的15%相近(χ^(2)=1.29,P=0.256)。结论:复明片联合曲伏前列素治疗POAG的效果较好,可快速缓解患者症状,降低眼压,改善眼表疾病指数与泪液指标,且不良反应发生率低。Objective:To investigate the effect of fuming tablets combined with travoprost on intraocular pressure and ocular surface disease index in glaucoma patients.Methods:This was a prospective cohort study.A simple random sampling method was used to collect 124 patients(124 eyes)with primary open angle glaucoma from the Department of Ophthalmology at Taizhou Municipal Hospital,from January 2021 to January 2022.According to the complete random number table,they were randomly divided into the control group and the observation group.In this study,62 patients(62 eyes)in the control group were treated with travoprost,while 62 patients(62 eyes)in the observation group were treated with fuming tablet combined with travoprost.All participants were treated for 3 months.The symptom alleviating time,intraocular pressure,ocular surface disease index(OSDI score),tear indicators[superoxide dismutase(SOD),nitric oxide(NO),malondialdehyde(MDA)],clinical efficacy,and adverse reactions(dry eyes,eyelid erythema,ocular congestion,ocular itching)were compared between the two groups using χ^(2) test and t test.Results:The alleviating time of blurred vision,ocular swelling,decreased vision,and headache in the observation group was shorter than that in the control group(t=7.79-16.36,all P<0.001).The intraocular pressure in the observation group after treatment was lower than that in the control group(t=13.56,P<0.001).The OSDI of the observation group after treatment was lower than that of the control group(t=19.01,P<0.001).After treatment,the level of SOD in the observation group was higher than that in the control group(t=13.11,P<0.001),while the level of NO and MDA in the observation group was lower than that in the control group(t=7.30,9.26,all P<0.001).The total effective rate of the observation group was 97%,higher than 84%in the control group(χ^(2)=5.91,P=0.015).The incidence of adverse reactions was 8%in the observation group and 15%in the control group,with no statistically significant difference(χ^(2)=1.29,P=0.256).Conclusions:Fu

关 键 词：青光眼 复明片 曲伏前列素 眼压 眼表疾病指数 

分 类 号：R775[医药卫生—眼科]