青光眼模型中线粒体自噬与视网膜神经节细胞损伤的关系  

Relationship between Mitophagy and Retinal Ganglion Cells Damage in Models of Glaucoma

作　　者：马海霞 胡欣欣 陆勤康 Haixia Ma;Xinxin Hu;Qinkang Lu(Department of Ophthalmology,the Affiliated People's Hospital,Ningbo University,Ningbo 315040,China)

机构地区：[1]宁波大学附属人民医院眼科中心,宁波315040

出　　处：《中华眼视光学与视觉科学杂志》2023年第5期396-400,共5页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：国家自然科学基金(82000887);浙江省自然科学基金(LY20C090001);宁波市2025重大科技项目(2021Z054);宁波市自然科学基金(2022J029);宁波市公益性科技计划项目(2022S052);宁波市眼科临床医学研究中心和宁波市医学重点学科建设项目资助(2016-S05)。

摘　　要：视网膜神经节细胞进行性丢失及其轴突损害是青光眼视神经损伤的主要病理生理机制,目前尚未明确其具体的损伤通路。线粒体自噬是一种选择性清除受损和功能障碍线粒体的过程,在维持细胞稳态中起着重要作用。最新的研究表明,线粒体自噬参与青光眼视网膜神经节细胞损伤的发生发展过程。笔者总结了各类实验性青光眼模型中线粒体自噬的相关研究,发现线粒体自噬对视网膜神经节细胞具有一定保护作用。因此,线粒体自噬有望成为青光眼视神经保护的治疗靶点。The progressive loss of retinal ganglion cells(RGC)and axonal damage are the main pathophysiological feature of glaucomatous retinal damage.The specific injury mechanism has not been well understood at present.Mitophagy is a process that selectively removes the damaged and dysfunctional mitochondria,which plays an important role in maintaining cellular homeostasis.Recent studies have shown that mitophagy is involved in the occurrence and development of retinal ganglion cells damage in glaucoma.In this review,we summarized the related researches in different models of glaucoma,and found that mitophagy plays a protective role in RGCs damage.Mitophagy is expected to become a therapeutic target for RGC neuroprotective in glaucoma.

关 键 词：线粒体自噬 视网膜神经节细胞 青光眼 视神经保护 

分 类 号：R775.1[医药卫生—眼科]