食管癌组织中表皮生长因子受体表达与根治性放疗敏感性及患者预后的关系  

Correlation of epidermal growth factor receptor expression in esophageal cancer tissues with sensitivity of radical radiotherapy and prognosis of patients

作　　者：吴佳 沈培佩 车俊 Wu Jia;Shen Peipei;Che Jun(Department of Radiation Oncology,Affiliated Hospital of Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学附属医院肿瘤放疗科,无锡214122

出　　处：《肿瘤研究与临床》2023年第4期258-262,共5页Cancer Research and Clinic

摘　　要：目的:分析食管癌组织中表皮生长因子受体(EGFR)的表达与根治性放疗敏感性及患者预后的关系。方法:选取2017年1月至2019年7月江南大学附属医院收治的98例食管癌患者,所有患者均接受根治性放疗,放疗4周后评估疗效,其中部分缓解(PR)+完全缓解(CR)为敏感组,疾病进展(PD)+疾病稳定(SD)为耐受组。采用免疫组织化学法检测癌组织与癌旁组织(距肿瘤组织边缘>5 cm)中EGFR的表达情况。比较癌组织与癌旁组织中EGFR表达情况,并比较敏感组与耐受组的临床病理特征。采用Cox比例风险模型分析食管癌患者预后影响因素;采用Kaplan-Meier法分析癌组织中EGFR表达情况与患者预后的关系。结果:食管癌组织中EGFR阳性表达率(66.3%,65/98)高于癌旁组织(29.6%,29/98),两组差异有统计学意义( χ^(2)=26.49, P<0.001)。98例患者均顺利完成根治性放疗,其中CR 4例,PR 60例,SD 26例,PD 8例。敏感组中高分化、肿瘤长径≤1.5 cm患者比例均高于耐受组,差异均有统计学意义(均 P<0.05)。敏感组癌组织中EGFR阳性表达率(56.3%,36/64)低于耐受组(85.3%,29/34),差异有统计学意义( χ^(2)=8.39, P<0.001)。多因素Cox回归分析结果显示,低分化、肿瘤长径>1.5 cm、EGFR阳性表达为食管癌患者总生存的独立危险因素(均 P<0.05)。EGFR阳性与阴性表达患者总生存比较,差异有统计学意义( χ^(2)=9.70, P=0.002)。 结论:食管癌组织中EGFR高表达,可能提示根治性放疗敏感性低、预后不良。Objective To analyze the correlation of epidermal growth factor receptor(EGFR)expression in esophageal cancer tissues with sensitivity of radical radiotherapy and prognosis of patients.Methods A total of 98 esophageal cancer patients admitted to the Affiliated Hospital of Jiangnan University from January 2017 to July 2019 were selected,and all patients received radical radiotherapy.The efficacy was assessed after 4 weeks of radiotherapy,partial remission(PR)+complete remission(CR)was treated as the sensitive group and disease progression(PD)+stable disease(SD)was treated as the tolerated group.The expression of EGFR in cancer tissues and paraneoplastic tissues(more than 5cm from the margin of cancer tissues)was measured by using immunohistochemistry.The expression of EGFR in cancer tissues and paraneoplastic tissues and the clinicopathological characteristics of the sensitive and tolerant groups were compared.Cox proportional risk model was used to analyze the factors influencing the prognosis of esophageal cancer patients;the Kaplan-Meier method was used to analyze the relationship between EGFR expression in cancer tissues and prognosis of patients.Results The positive expression rate of EGFR in esophageal cancer tissues(66.3%,65/98)was higher than that in paraneoplastic tissues(29.6%,29/98),and the difference between the two groups was statistically significant(χ^(2)=26.49,P<0.001).All 98 patients successfully completed radical radiotherapy,including 4 cases of CR,60 cases of PR,26 cases of SD and 8 cases of PD.The proportion of patients with highly differentiated and tumor length≤1.5 cm in the sensitive group was higher than that in the tolerant group,and the differences were statistically significant(all P<0.05).The positive expression rate of EGFR in cancer tissues in the sensitive group(56.3%,36/64)was lower than that in the tolerant group(85.3%,29/34),and the difference between the two groups was statistically significant(χ^(2)=8.39,P<0.001).Multifactorial Cox regression analysis showed that poor diffe

关 键 词：食管肿瘤 表皮生长因子受体 根治性放疗 敏感性 预后 

分 类 号：R735.1[医药卫生—肿瘤]