酒精依赖伴吸烟行为患者慢性戒断期时间知觉及跨期决策的特征研究  

The Profiles of Time Perception and Inter-temporal Choice in Alcohol Dependent Patients with Smoking Behavior During Chronic Withdrawal Period

作　　者：徐阳阳 李斌 陈旭[2,3] XU Yangyang;LI Bin;CHEN Xu(Binzhou Medical University,Yantai 264003,Shandong,China;Shandong Mental Health Center,Jinan 250014,Shandong,China;Shandong University Cheeloo College of Medicine,Jinan 250012,China)

机构地区：[1]滨州医学院,山东烟台264003 [2]山东省精神卫生中心,山东济南250014 [3]山东大学齐鲁医学院,山东济南250012

出　　处：《中国药物滥用防治杂志》2023年第5期750-755,771,共7页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：山东省医药卫生科技发展计划面上项目(编号:2016WS0398)。

摘　　要：目的:探讨酒精依赖(AD)伴吸烟行为患者慢性戒断期时间知觉及跨期决策的特征.方法:采用方便取样的方法选取AD伴轻度吸烟行为患者(Light Smoking,LS组,n=22)、AD伴重度吸烟行为患者(Heavy Smoking,HS组,n=42)、健康被试者(Health Control,HC组,n=42).临床研究采用酒精依赖戒断评估量表(CIWA-Ar)评估被试戒断反应严重程度;应用时间再现任务(TRT)评估感知计时能力;应用时间辨别任务(TDT)评估运动计时能力;应用延迟折扣任务(DDT)评估被试跨期决策特征.结果:AD组1 s和2 s时距时Drr值大于HC组(P<0.05);在6组时距中,AD组CV值大于HC组(P<0.05);LS组与HS组Drr值与CV值比较,差异均无统计学意义(P>0.05).AD组b值低于HC组(P<0.01);而LS组b值与HS组比较,差异无统计学意义(P>0.05).在较小(SS=10)及较大的金额条件下(SS=100),AD组k值大于HC组(P<0.05);HS组k值均显著大于LS组(P<0.01).结论:AD患者存在时间知觉及跨期决策方面的偏向,伴重度吸烟行为AD患者跨期决策的偏向更为突出.Objective:To explore the profiles of the time perception and the inter-temporal choice in alcohol dependent patients with smoking behavior during chronic withdrawal period.Methods:AD patients with light smoking behavior(Light Smoking,LS group,n=22),AD patients with heavy smoking behavior(Heavy Smoking,HS group,n=42)and healthy subjects(Health Control,HC group,n=42)were selected by convenient sampling method.The severity of withdrawal response was assessed using the Alcohol Dependence Withdrawal Assessment Scale(CIWA-Ar).The time reproduction task(TRT)was used to evaluate the perceptual timing ability.Time discrimination task(TDT)was used to evaluate the motor timing ability.The delayed discounting task(DDT)was used to evaluate the characteristics of inter-temporal decision-making.Results:Drr values in AD group were higher than thosein HC group in 1 s and 2 s time intervals(P<0.05);CV values of AD group were higher than those of HC group in 6 groups of time intervals(P<0.05).There was no significant difference in Drr values and CV values between LS group and HS group(P>0.05).b value of patients in AD group was lower than that in HC group(P<0.01);while there was no significant difference in b value between LS group and HS group(P>0.05).Under the condition of smaller(SS=10)and larger amount(SS=100),k values of AD group were significantly higher than those of HC group(P<0.05),meanwhile,k values of HS group were significantly higher than thoseof LS group(P<0.01).Conclusion:AD Patients show bias in both time perception and inter-temporal choice,and AD patients with heavy smoking behavior show bias in inter-temporal choice prominently.

关 键 词：酒精依赖 吸烟 时间知觉 跨期决策 延迟折扣 

分 类 号：R749.62[医药卫生—神经病学与精神病学] R163[医药卫生—临床医学]