溃疡性结肠炎患者血清白细胞介素-28B水平与临床特征的相关性  

The correlation between serum interleukin-28B levels and clinical characteristics in patients with ulcerative colitis

作　　者：宋香谆[1] 齐玲芝[1] 裴艳娟[1] 朱威 王雪娇 SONG Xiang-zhun;QI Ling-zhi;PEI Yan-juan(Department of Gastroenterology,The People's Hospital of Jilin Province,Changchun 130021,China)

机构地区：[1]吉林省人民医院消化科,吉林长春130021

出　　处：《吉林医学》2023年第6期1462-1464,共3页Jilin Medical Journal

基　　金：吉林省卫生健康科技创新自筹经费项目[项目编号:2019zc010]。

摘　　要：目的:探讨白细胞介素(IL-)28B与溃疡性结肠炎(UC)的相关性。方法:选取UC患者68例,住院期间使用5-氨基水杨酸(5-ASA)规律治疗。选取60例健康人作为对照组。用酶联免疫吸附试验(ELISA)检测UC患者治疗前治疗后及60例健康对照血清IL-28B水平。收集UC患者各项临床资料,统计上述各项指标与血清IL-28B水平的相关性。结果:UC患者与健康人的IL-28B的表达水平不同,并且疾病的活动程度、核周型抗中性粒细胞胞质抗体(pANCA)阳性对IL-28B血清表达水平有影响。5-ASA能够减轻患者的炎性反应,病情好转后的UC患者IL-28B表达水平升高。结论:UC与IL-28B的表达水平有一定相关性,并且疾病的活动程度、pANCA的阳性对IL-28B血清表达水平有影响。5-ASA能减轻患者的炎性反应,病情好转后的患者IL-28B表达水平升高,预测IL-28B可以在UC的病程中起到保护作用。Objective To explore of the correlation between Interleukin(IL)-28B and Ulcerative colitis(UC).Method We selected 68 patients who treated with 5-Aminosalicylic acid(5-ASA).And 60 healthy people as the control group.IL-28B levels were measured by enzyme-linked immunosorbent assay(ELISA)in 68 UC patients before and after treatment,and the IL-28B levels were also detected by ELISA in the 60 healthy controls.Collect patient clinical data,analyze the effects of the above indexes on serum IL-28B expression.Results The expression level of IL-28B varies between UC patients and healthy individuals,and the degree of disease activity and positive pANCA have an impact on the serum expression level of IL-28B.5-ASA can alleviate the inflammatory response of patients,and the expression level of IL-28B increases in UC patients after improvement.Conclusion The expression level of IL-28B was correlated with ulcerative colitis,and the degree of disease activity and positive pANCA have an impact on the serum expression level of IL-28B.5-ASA can alleviate the inflammatory response of patients,and the expression level of IL-28B increases in UC patients after improvement,it is predicted that IL-28B can play a protective role in the progression of UC.

关 键 词：溃疡性结肠炎 白细胞介素-28B Mayo评分 5-氨基水杨酸 

分 类 号：R574.62[医药卫生—消化系统]