多烯磷酯酰胆碱联合泼尼松不同减量方式对自身免疫性肝炎患者血清淋巴细胞亚群的影响  

Influence of polyene phosphatidylcholine injections combined with a gradual reduction in prednisone dosage on serum lymphocyte subsets in patients with autoimmune hepatitis

作　　者：王林[1] 李罗红[1] 钟敏 达鹏然 杨小莉[1] WANG Lin;LI Luohong;ZHONG Min(Department of Gastroenterology,West China Hospital of Sichuan University,Sichuan,Chengdu 611130,China)

机构地区：[1]四川大学华西医院消化内科,成都市611130

出　　处：《河北医药》2023年第11期1657-1660,共4页Hebei Medical Journal

摘　　要：目的研究在自身免疫性肝炎治疗中应用多烯磷酯酰胆碱注射液联合泼尼松缓慢减量效果及对患者血清淋巴细胞亚群的影响。方法纳入2020年3月至2022年2月收治的94例自身免疫性肝炎患者为研究对象,应用随机数字表法分为对照组和观察组,每组47例。对照组给予多烯磷酯酰胆碱注射液联合泼尼松快速减量治疗,观察组给予多烯磷酯酰胆碱注射液联合泼尼松缓慢减量,观察2组治疗前后肝功能、血清免疫球蛋白及血清淋巴细胞亚群指标变化,并统计2组用药期间不良反应发生情况。结果治疗前2组肝功能、血清免疫球蛋白及血清淋巴细胞亚群指标差异无统计学意义(P>0.05);治疗后观察组丙氨酸氨基转移酶(ALT)、碱性磷酸酶(ALP)、天冬氨酸转移酶(AST)、谷氨酰转移酶(GGT)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、白细胞分化抗原3(CD3^(+))、白细胞分化抗原5(CD5^(+))、白细胞分化抗原8(CD8^(+))和白细胞分化抗原19(CD19^(+))均低于对照组(P<0.05);2组用药不良反应发生率差异无统计学意义(P>0.05)。结论多烯磷酯酰胆碱注射液联合泼尼松缓慢减量治疗自身免疫性肝炎效果良好,改善肝功能和免疫功能效果良好,用药不良反应较少,治疗有效性和安全性较高。Objective To analyze the influence of polyene phosphatidylcholine injections combined with a gradual reduction in prednisone dosage on serum lymphocyte subsets in patients with autoimmune hepatitis.Methods A total of 94 patients with autoimmune hepatitis admitted from March 2020 to February 2022 were enrolled as the research objects.They were randomly allocated to control group and observation group,with 47 cases in each group.All patients were given to polyene phosphatidylcholine injections,and a rapid and a slow reduction in prednisone dosage were given to those of control group and observation group,respectively.Liver function,serum immunoglobulin levels and serum indexes of lymphocyte subsets before and after treatment between groups were compared.The incidence of adverse events during the experimental process was recorded.Results Before treatment,there were no significant differences in the liver function,serum immunoglobulin levels and serum lymphocyte subsets between the two groups(P>0.05).After treatment,alanine aminotransferase(ALT),alkaline phosphatase(ALP),aspartate aminotransferase(AST),glutamyltransferase(GGT),immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG),leukocyte differentiation antigen 3(CD3^(+)),leukocyte differentiation antigen 5(CD5^(+)),leukocyte differentiation antigen 8(CD8^(+))and leukocyte differentiation antigen 19(CD19^(+))were significantly lower in the observation group than those in the control group(P<0.05).There was no significant difference in the incidence of adverse events between groups(P>0.05).Conclusion Polyene phosphatidylcholine injections combined with a gradual reduction in prednisone dosage has a good effect on improving liver function and immune function,with less adverse events,and high therapeutic efficacy and safety in patients with autoimmune hepatitis.

关 键 词：多烯磷酯酰胆碱注射液 泼尼松 缓慢减量 自身免疫性肝炎 血清淋巴细胞亚群 

分 类 号：R575.1[医药卫生—消化系统]