富血小板纤维蛋白与Bio-Oss骨粉在上颌窦底外提升术中应用价值对比研究  

A Comparative Study on the Application Value of PRF and Bio-Oss Bone Powder in Extra-Maxillary Sinus Lift Surgery

作　　者：丁明会 孔令兵 杨京宇 丁明智 DING Minghui;KONG Lingbing;YANG Jinyu(Chengde Stomatological Hospital,Hebei Chengde 067000,China)

机构地区：[1]河北省承德市口腔医院口腔种植科,河北承德067000 [2]河北省承德市中医院口腔科,河北承德067000

出　　处：《河北医学》2023年第6期990-995,共6页Hebei Medicine

基　　金：河北省承德市科学技术研究与发展计划项目,(编号:201904A007)。

摘　　要：目的:探讨富血小板纤维蛋白(PRF)与Bio-Oss骨粉应用于颌窦底外提升术中的临床价值对比研究。方法:选取2020年7月至2022年1月就诊于我院并接受上颌窦底外提升术疗法的患者120例,随机数字表法简单随机分为PRF组58例,Bio-Oss组62例,PRF组采用富血小板纤维蛋白(PRF)植入干预手术方式,Bio-Oss组采用Bio-Oss骨粉植入干预手术方式,观察两组患者疼痛情况、手术部位黏膜情况、术后骨缺损再生情况及周围软组织健康状况、骨密度变化情况,两组患者治疗前后血小板衍生生长因子(PDGF)、血管内皮生长因子(VEGF)、转化生长因子-β(TGF-β)指标水平,Pearman分析骨密度与PDGF、VEGF、TGF-β的相关性。结果:PRF组疼痛表现较Bio-Oss组明显降低,PRF组中黏膜颜色正常的患者比例较Bio-Oss组明显更高,黏膜肿胀程度较Bio-Oss组显著降低;PRF组患者出血指数、探诊深度、附着丧失指标水平较Bio-Oss组明显降低,PRF组植骨高度、成骨厚度指标较Bio-Oss组明显升高(均P<0.05);术后1个月两组患者骨密度较术前水平均明显下降,但PRF组骨密度水平比Bio-Oss组更高(P<0.05);Bio-Oss组术后3个月骨密度值较术后1个月明显升高,但明显低于术前水平,且明显低于PRF组(均P<0.05);PRF组中各指标水平较Bio-Oss组显著升高(均P<0.05);Pearson相关性分析骨密度与生长因子PDGF、VEGF、TGF-β指标水平,均呈正相关(P<0.05)。结论:针对患者行上颌窦底外提升术时植入PRF可以促进上颌窦内早期新骨形成,能取得良好的临床效果。Objective:To investigate the clinical value of platelet-rich fibrin(PRF)and Bio-Oss bone meal in the clinical value of extra-maxillary sinus lift surgery.Methods:A total of 120 patients who were treated in our hospital from July 2020 to January 2021 and received extra-maxillary sinus lift surgery were selected and simply randomly divided into 58 patients in PRF group and 62 patients in Bio-Oss group by random number table method,with platelet-rich fibrin(PRF)implantation intervention procedure in PRF group and Bio-Oss bone powder implantation intervention procedure in Bio-Oss group.Pain,mucosa at the surgical site,postoperative bone defect regeneration and surrounding soft tissue health were observed in the two groups,bone density changes,platelet-derived growth factor(PDGF),vascular endothelial growth factor(VEGF),transforming growth factor-β(TGF-β)index levels before and after treatment in both groups,Pearman analysis of bone density and PDGF,VEGF,TGF-βcorrelation was conducted.Results:Pain performance was significantly lower in the PRF group compared with the Bio-Oss group,the proportion of patients with normal mucosal color was significantly higher in the PRF group compared with the Bio-Oss group,and the degree of mucosal swelling was significantly lower compared with the Bio-Oss group;the levels of bleeding index,probing depth,and attachment loss index were significantly lower in the PRF group compared with the Bio-Oss group,and the bone graft height and osteogenic thickness index were significantly higher in the PRF group compared with the Bio-Oss group.Oss group(all P<0.05);BMD in both groups decreased significantly compared to the preoperative level 1 month after surgery,but the PRF group had a higher BMD level than the Bio-Oss group(P<0.05);BMD values in the Bio-Oss group increased significantly at 3 months after surgery compared to 1 month after surgery,but were significantly lower than the preoperative level and significantly lower than the PRF group(all P<0.05);.The levels of each index in the PRF

关 键 词：富血小板纤维蛋白 BIO-OSS骨粉 上颌窦底外提升术 骨密度 生长因子 

分 类 号：R783.6[医药卫生—口腔医学]