腹腔镜下子宫肌瘤剔除术后患者血清CA-199、CEA表达及预测术后复发  

Expressions of serum carbohydrate antigen 199 and carcinoembryonic antigen after laparoscopic myomectomy and their predictive values for the recurrence of myoma of uterus

作　　者：邵瑾 何末琴 SHAO Jin;HE Moqin(Changxing Branch of Children's Hospital(Changxing County Maternal and Child Health Cre Hospital),School of Medicine Zhejiang University,Huzhou,Zhejiang Province,313100)

机构地区：[1]浙江大学医学院附属儿童医院长兴分院,长兴县妇幼保健院,湖州313100

出　　处：《中国计划生育学杂志》2023年第6期1379-1383,共5页Chinese Journal of Family Planning

基　　金：湖州市科学技术局项目(2016GY82)。

摘　　要：目的:检测腹腔镜下子宫肌瘤剔除术患者血清糖类抗原199(CA199)、癌胚抗原(CEA)表达水平,并探讨二者与术后肌瘤复发的关系及预后价值。方法:选取2016年1月-2020年1月本院行腹腔镜下子宫肌瘤剔除术患者100例临床资料,根据术后6个月复发与否分为复发组23例、未复发组77例。收集并比较两组患者年龄、手术时间、术中出血量、排气时间、住院时间及手术情况;酶联免疫吸附法测定术前及术后血清CA-199、CEA水平;二元logistic回归分析影响患者术后复发的危险因素;利用受术者工作特征曲线(ROC)评估术后24 h血清CA-199、CEA水平对患者术后复发的诊断价值。结果:两组术后24 h、术后6个月血清CA-199、CEA水平均低于术前,且复发组高于未复发组(P<0.05)。二元回归分析显示,患者术后24 h血清CA-199、CEA水平高表达是术后复发的危险因素(P<0.05)。ROC曲线显示,术后24 h血清CA-199、CEA水平诊断患者复发的曲线下面积(AUC)分别为0.852、0.838,二者联合检测诊断术后肌瘤复发的AUC为0.937。结论:腹腔镜下子宫肌瘤剔除术后24 h血清CA-199、CEA水平异常高表达与术后复发关系密切,二者联合检测对复发有一定预后价值。Objective:To detect the expression levels of serum carbohydrate antigen 199(CA199)and carcinoembryonic antigen(CEA)of patients after laparoscopic myomectomy,to explore the correlation between the levels of CA199 and CEA of the patients and the recurrence of their myoma of uterus,and to study the predictive values of the levels of CA199and CEA for the recurrence of myoma of uterus.Methods:The clinical data of 100patients with laparoscopic myomectomy from January 2016to January 2020were selected as the research objects.These patients were divided into group A(23cases with the recurrence of myoma of uterus)and group B(77cases without the recurrence of myoma of uterus)according to the recurrence situation in 6months after operation.The age,the operation time,the intraoperative blood loss,the exhaust time,the hospital stay,and the operative conditions of the patients were collected and were compared between the two groups.The levels of serum CA 199and CEA of the patients in the two groups before and after operation were measured by enzyme linked immunosorbent assay(ELISA).Binary Logistic regression analysis was used to analyze the risk factors affecting the postoperative recurrence of myoma of uterus of the patients.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic values of the serum CA 199and CEA levels of the patients in 24hafter operation for their postoperative recurrence of myoma of uterus.Results:The serum CA 199and CEA levels of the patients in the two groups in postoperative 24hand in postoperative 6months were significantly lower than those before operation,and which of the patients in group A were significantly higher than those of the patients in group B(P<0.05).Binary regression analysis showed that the high expressions of the serum CA 199and CEA levels of the patients in postoperative 24hwere the risk factors for their postoperative recurrence of myoma of uterus(P<0.05).ROC curve shows that the area under curve(AUC)of the serum CA 199level,the CEA level,and the combined leve

关 键 词：腹腔镜下子宫肌瘤剔除术 糖类抗原199 癌胚抗原 术后复发 

分 类 号：R737.33[医药卫生—肿瘤]