p16/Ki67双染检测预测宫颈非典型鳞状上皮增生病变转归价值  

Clinical value of p16/Ki67 double staining detection for predicting the prognosis outcomes of the cervical atypical squamous hyperplasia

作　　者：李贇 王彩红[1] 潘晋兵[1] LI Yun;WANG Caihong;PAN Jinbing(Shanxi Provincial Maternal and Child Health Care Hospital,Taiyuan,Shanxi Province,030000)

机构地区：[1]山西省妇幼保健院,太原030000

出　　处：《中国计划生育学杂志》2023年第6期1465-1468,1498,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨p16/Ki67双染检测预测宫颈TCT非典型鳞状上皮增生病变转归价值。方法:选取2019年7月-2020年6月本院初诊的非典型鳞状上皮增生患者610例临床资料,根据随访1年后患者疾病转归情况分为病变进展组、持续组、消退组,分析3组一般资料、TCT以及p16/Ki67双染检测结果,分析p16/Ki67双染检测预测非典型鳞状上皮增生预后价值;根据p16/Ki67双染检测结果将患者分为阳性组与阴性组,分析随访第1年后p16/Ki67双染检测结果与非典型鳞状上皮增生病变转归相关性。结果:随访1年后,610例消退150例(24.6%),持续342例(56.1%),进展118例(19.3%)。进展组p16/Ki67双染检测阳性率(67.8%)高于持续组(29.8%)和消退组(14.0%)(P<0.05)。p16/Ki67双染检测的灵敏度为0.287,特异性为0.760,阳性预测值为76.9%,阴性预测值为40.7%。随访1年后发现,阳性组癌变率(65.5%)高于阴性组(2.7%)(P<0.05)。p16/Ki67双染检测阳性结果与非典型鳞状上皮增生进展率呈正相关(P<0.05)。结论:p16/Ki67双染检测预测宫颈TCT非典型鳞状上皮增生病变转归有临床价值。Objective:To study the value of p16/Ki67double staining detection for predicting the prognosis outcomes of the cervical atypical squamous hyperplasia.Methods:The clinical data of 610patients who had been diagnosed with atypical squamous hyperplasia from July 2019to June 2020were selected in this study.After 1year of follow up,these patients were divided into group A(patients with progressive cervical atypical squamous hyperplasia),group B(patients with continuous cervical atypical squamous hyperplasia),and group C(patients with regression of cervical atypical squamous hyperplasia)according to the prognosis outcomes of the cervical atypical squamous hyperplasia.The general data,and the results of TCT and p16/Ki67double staining detection of the patients in the three groups were analyzed.The value of the result of p16/Ki67double staining detection for predicting their cervical atypical squamous hyperplasia was analyzed.Based on the p16/Ki67double staining detection result,these patients were divided into group 1(patients with positive result)and group 2(patients with negative result).The correlation between the results of p16/Ki67double staining detection of the patients after 1year of follow up and their prognosis outcomes of the cervical atypical squamous hyperplasia was analyzed.Results:After 1year of follow-up,among 610patients,150(24.6%)patients were in group C,342(56.1%)patients were in group B,and 118(19.3%)patients were in group A.The positive rate of p16/Ki67double staining detection(67.8%)of the patients in group A was significantly higher than that(29.8%)of the patients in group B and that(14.0%)of the patients in group C(P<0.05).The sensitivity,the specificity,the positive predictive value,and the negative predictive value of the result of p16/Ki67double staining detection of the patients for predicting their prognosis outcomes of cervical atypical squamous hyperplasia were 0.287,0.760,76.9%,and 40.7%,respectively.The canceration rate of the cervical atypical squamous hyperplasia(65.5%)of the patients i

关 键 词：宫颈非典型鳞状上皮增生 p16/Ki67双染检测 病变转归 预测 

分 类 号：R737.33[医药卫生—肿瘤]