大肠癌组织及外周血相关分子诊断标志物研究现状概述  

Overview of research status of molecular diagnostic markers related to colorectal cancer tissue and peripheral blood

作　　者：张治宽 王雅楠 屈莲平 张小凤 石彩冬 李兆桓 邹敏 高峰 ZHANG Zhikuan;WANG Yanan;QU Lianping;ZHANG Xiaofeng;SHI Caidong;LI Zhaohuan;ZOUMin;GAO Feng(Clinical College of Traditional Chinese Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu,China,730000;Gansu Provincial Key Laboratory of Stem Cells and Gene Medicine,Lanzhou,Gansu,China,730050;Colorectal and Anal Surgery,No.940 Hospital,Joint Logistics Support Force of the Chinese People's Liberation Army,Lanzhou,Gansu,China,730050)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000 [2]甘肃省干细胞与基因药物重点实验室,甘肃兰州730050 [3]中国人民解放军联勤保障部队第九四〇医院结直肠肛门外科,甘肃兰州730050

出　　处：《分子诊断与治疗杂志》2023年第5期725-728,732,共5页Journal of Molecular Diagnostics and Therapy

基　　金：甘肃省科技计划项目(重点研发计划)(20YF8FA098)。

摘　　要：大肠癌(CRC)是胃肠道最常见的恶性肿瘤之一,严重威胁着人类的健康。研究发现,对肿瘤标志物的检测是临床发现CRC无症状患者的重要线索之一,随着生物化学、免疫和分子生物学等技术的快速发展,肿瘤标志物的研究已在肿瘤早期诊断、疗效监测、预后评估等方面得到了广泛的应用。本文旨在对CRC相关肿瘤标记物,包括酶类标志物、糖蛋白抗原类标志物等作一综述,以期为CRC的诊疗提供新的思路和方向。Colorectal cancer(CRC)is one of the most common malignant tumors in the gastrointestinal tract,which seriously threatens human health.Studies have found that the detection of tumor markers is one of the important clues to clinically discover asymptomatic patients with CRC.With the rapid development of technologies such as biochemistry,immunity and molecular biology,the study of tumor markers has played an important role in the early diagnosis and curative effect of tumors.It has been widely used in monitoring and prognosis assessment.This article aims to review CRC⁃related tumor markers,including enzyme markers and glycoprotein antigen markers,in order to provide new ideas and directions for the diagnosis and treatment of CRC.

关 键 词：肿瘤标志物 大肠癌 综述 

分 类 号：R735.34[医药卫生—肿瘤]