鸟嘴形切口整形保乳术对乳腺癌术后美观效果及血清VEGF、MMP⁃9及T淋巴细胞亚群的影响  

Effect of plastic and breast conserving surgery with beak shaped incision on postoperative beauty and serum VEGF,MMP⁃9 and T lymphocyte subsets in breast cancer patients

作　　者：王绪麟[1] 刘新梅[1] 孟娟[2] 李慧璇 WANG Xulin;LIU Xinmei;MENG Juan;LI Huixuan(Department of Breast and Thyroid Surgery,Haikou People's Hospital,Haikou,Hainan,China,570100;Department of Oncology,Haikou People's Hospital,Haikou,Hainan,China,570100)

机构地区：[1]海口市人民医院乳腺甲状腺外科,海南海口570100 [2]海口市人民医院肿瘤内科,海南海口570100

出　　处：《分子诊断与治疗杂志》2023年第5期797-800,804,共5页Journal of Molecular Diagnostics and Therapy

基　　金：海南省卫生健康委科研项目(ZZA2000123)。

摘　　要：目的探讨鸟嘴形切口整形保乳术对乳腺癌术后美观效果及血清基质金属蛋白酶-9(MMP-9)和血管表皮生长因子(VEGF)及T淋巴细胞亚群的影响。方法选取2020年1月至2022年1月于海口市人民医院乳腺外科行肿瘤整形术的Ⅰ~Ⅱ期乳腺癌患者作为研究对象,按照切口类型将患者分为观察组(使用鸟嘴切口,n=50)和对照组(使用半月形切口,n=50),比较两组的双乳对称性评分、综合美学效果评分、术前术后血清VEGF、MMP-9、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平、并发症发生率、外形满意度。结果观察组的双乳对称性评分及综合美学效果评分明显高于对照组,差异有统计学意义(t=8.171、4.502,P均<0.05)。术后观察组的血清VEGF、MMP⁃9明显低于对照组,差异有统计学意义(t=2.755、5.962,P均<0.05)。术后观察组的CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)明显高于对照组,差异具有统计学意义(t=4.081、4.193、5.613,P均<0.05)。对照组的并发症总发生率为2.00%,明显低于对照组的18.00%,差异有统计学意义(χ^(2)=7.111,P<0.05)。观察组患者的外形满意度为88.00%明显高于对照组的58.00%,差异有统计学意义(χ^(2)=11.416,P<0.05)。结论鸟嘴形切口整形保乳术能够提高术后美观度,降低血清VEGF、MMP-9水平,维持免疫功能的稳定,并且降低并发症发生的风险,提高患者的满意度。Objective To investigate the effect of plastic and breast conserving surgery with beak shaped incision on the postoperative beauty of breast cancer and the influence of serum matrix metalloproteinase⁃9(MMP⁃9),vascular epidermal growth factor(VEGF)and T lymphocyte subsets.Methods The patients with stageⅠ~Ⅱbreast cancer who underwent tumor plastic surgery in the breast surgery department of Haikou Peo⁃ples Hospital from January 2020 to January 2022 were selected as the research objects.According to the type of incision,the patients were divided into the observation group(using the beak incision,n=50)and the control group(using the half⁃moon incision,n=50).The symmetry score of the two breasts,the comprehensive aesthet⁃ic effect score,the level of serum VEGF,MMP⁃9,CD4+,CD8+,CD4+/CD8+before and 3 days after surgery were compared between the two groups.The incidence of complications and satisfaction with appearance were also compared betweeb the two groups.Results The symmetry score and comprehensive aesthetic effect score in the observation group were significantly higher than those in the control group,with statistically significant differences(t=8.171、4.502,P<0.05).The serum VEGF and MMP⁃9 levels in the observation group were signif⁃icantly lower than those in the control group(t=2.755、5.962,P<0.05).CD4+,CD8+、CD4+/CD8+in the obser⁃vation group were significantly higher than those in the control group after operation,with a statistically signifi⁃cant difference(t=4.081,4.193,5.613,P<0.05).The total incidence of complications in the control group was 2.00%,significantly lower than in the control group(18.00%)(χ^(2)=7.111,P<0.05).The appearance satisfac⁃tion of the patients in the observation group was 88.00%,which was significantly higher than that in the control group(58.00%)(χ^(2)=11.416,P<0.05).Conclusion The plastic and breast conserving surgery with beak shaped incision can improve the postoperative beauty,reduce the levels of serum VEGF and MMP⁃9,maintain the stability of imm

关 键 词：鸟嘴形切口整形保乳术 乳腺癌术后 美观效果 血清VEGF MMP⁃9 T淋巴细胞亚群 

分 类 号：R737.9[医药卫生—肿瘤]