多发性骨髓瘤患者血清miR-451、miR145-3p变化及临床意义  

Changes and clinical significance of serum miR⁃451 and miR145⁃3p in patients with multiple myeloma

作　　者：杨超[1] 梁淑新[1] 齐霁 冉京萍 朱姗姗[1] 钟利英 李铁民[1] YANG Chao;LIANG Shuxin;QI Ji;RAN Jingping;ZHU Shanshan;ZHONG Liying;LI Tiemin(Department of Laboratory Medicine,the Affiliated Hospital of Hebei University,Baoding,Hebei,China,071000)

机构地区：[1]河北大学附属医院检验科,河北保定071000

出　　处：《分子诊断与治疗杂志》2023年第5期854-857,862,共5页Journal of Molecular Diagnostics and Therapy

基　　金：保定市科技计划项目(2241ZF300)。

摘　　要：目的探究多发性骨髓瘤(MM)患者血清微小核糖核酸⁃451(miR⁃451)、微小核糖核酸145⁃3p(miR145⁃3p)变化及临床意义。方法选取河北大学附属医院于2021年1月至2022年10月收治的60例MM患者纳入观察组,根据初诊情况将患者分为复发组(n=12)与初诊组(n=48),选取同期于医院体检的45名健康者作为对照组,检测各组血清miR⁃451、miR145⁃3p水平,采用受试者工作(ROC)曲线分析两者对于MM的诊断价值。结果观察组血清miR⁃451、miR145⁃3p低于对照组,差异有统计学意义(P<0.05);MM国际分期系统(ISS):Ⅰ期13例,Ⅱ期19例,Ⅲ期28例,miR⁃451、miR145⁃3p水平:Ⅲ期<Ⅱ期<Ⅰ期,差异均有统计学意义(P<0.05);复发组血清miR⁃451、miR145⁃3p水平低于初诊组,差异有统计学意义(P<0.05);血清miR⁃451、miR145⁃3p诊断MM时,以miR145⁃3p的曲线下面积值(AUC)值最高,敏感度、特异度分别为95.00%、93.33%,两者联合诊断的AUC值为0.844,敏感度100.00%,特异度为84.44%。结论血清miR⁃451、miR145⁃3p在MM患者中呈现低表达,且随患者病情加重逐渐下降,诊断效能较好,因此临床可将血清miR⁃451、miR145⁃3p作为判断MM患者病情变化的指标。Objective To explore the changes and clinical significance of serum micro ribonucleic acid 451(miR⁃451)and micro ribonucleic acid 145⁃3p(miR145⁃3p)in patients with multiple myeloma(MM).Methods A total of 60 patients with MM admitted to the Affiliated Hospital of Hebei University from January 2021 to October 2022 were selected as the observation group.According to the results of initial diagnosis,the patients were divided into the recurrence group(n=12)and the initial diagnosis group(n=48).Meanwhile,45 healthy individuals were selected as the control group.Serum miR⁃451 and miR145⁃3p levels in each group were detected,and their diagnostic value for MM was analyzed using the receiver operating characteristic(ROC)curves.Results Serum miR⁃451 and miR145⁃3p levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).MM international staging system(ISS)showed that there were 13 patients at stageⅠ,19 patients at stageⅡ,and 28 patients at stageⅢ.Serum miR⁃451 and miR145⁃3p levels decreased in order from stageⅠ,stageⅡto stageⅢ,and the differences were statistically significant(P<0.05).Serum miR⁃451 and miR145⁃3p levels in the recurrence group were lower than those in the initial diagnosis group,and the differences were statistically significant(P<0.05).Compared with miR⁃451,the area under the curve(AUC)of miR145⁃3p was larger for diagnosing MM,and its sensitivity and specificity were 95.00%and 93.33%.The AUC,sensitivity,and specificity of serum miR⁃451 combined with miR145⁃3p in the diagnosis of MM were 0.844,100.00%and 84.44%.Conclusion Serum miR⁃451 and miR145⁃3p show low expression in MM patients,and gradually decrease as the patients condition worsens,and the diagnostic efficiency is good.Therefore,serum miR⁃451 and miR145⁃3p can be used as clinical indicators to judge the condition change of MM patients.

关 键 词：多发性骨髓瘤 血清微小核糖核酸⁃451 血清微小核糖核酸145⁃3p 

分 类 号：R733.3[医药卫生—肿瘤]