Design of Protein Segments and Peptides for Binding to Protein Targets  

作　　者：Suchetana Gupta Noora Azadvari Parisa Hosseinzadeh 

机构地区：[1]Knight Campus Center for Accelerating Scientific Impact,University of Oregon,Eugene OR 97403,USA

出　　处：《BioDesign Research》2022年第1期312-336,共25页生物设计研究（英文）

基　　金：NIH grant DP2GM146249 for funding and support.

摘　　要：Recent years have witnessed a rise in methods for accurate prediction of structure and design of novel functional proteins. Designof functional protein fragments and peptides occupy a small, albeit unique, space within the general field of protein design. Whilethe smaller size of these peptides allows for more exhaustive computational methods, flexibility in their structure and sparsity ofdata compared to proteins, as well as presence of noncanonical building blocks, add additional challenges to their design. Thisreview summarizes the current advances in the design of protein fragments and peptides for binding to targets and discussesthe challenges in the field, with an eye toward future directions.

关 键 词：DIRECTIONS OCCUPY CANONICAL 

分 类 号：O62[理学—有机化学]