CANONICAL

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Crosstalk among canonical Wnt and Hippo pathway members in skeletal muscle and at the neuromuscular junction
《Neural Regeneration Research》2025年第9期2464-2479,共16页Said Hashemolhosseini Lea Gessler 
supported by the German Research Council(Deutsche Forschungsgemeinschaft,HA3309/3-1/2,HA3309/6-1,HA3309/7-1)。
Skeletal muscles are essential for locomotion,posture,and metabolic regulation.To understand physiological processes,exercise adaptation,and muscle-related disorders,it is critical to understand the molecular pathways...
关键词：canonical Wnt"Wingless-related integration site"pathway beta-catenin(CTNNB1) Hippo pathway MYOGENESIS MYOTUBE neuromuscular junction satellite cell skeletal muscle fiber transcriptional co-activator with PDZ-binding motif(TAZ) T-cell-specific transcription factor/lymphoid enhancer-binding factor(TCF/LEF) TEA domain family member(TEAD) transducin-like enhancer of split(TLE) yes-associated protein 1(YAP1) 
The non-canonical proteome:a novel contributor to cancer proliferation
《Cell Research》2025年第3期155-156,共2页Jorge Ruiz-Orera Norbert Hübner 
The non-canonical proteome,comprising hundreds of unannotated peptides encoded by small open reading frames,significantly expands the functional landscape of our genome beyond conventional protein-coding genes.Recent ...
关键词：small peptides detection techniques cancer biologyadvan cell research mass spectrometry non canonical proteome ribo seq small open reading framessignificantly 
Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets
《Neural Regeneration Research》2025年第3期725-739,共15页Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler 
funded by NIH-NIA R01AG061708 (to PHO);Patrick Grange Memorial Foundation (to PHO);A Long Swim (to PHO);CureSPG4 Foundation (to PHO)。
Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understan...
关键词：ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST SPASTIN 
Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer:distinct and concerted control
《Frontiers of Medicine》2025年第1期23-52,共30页Xianzhe Huang Wenwei Chen Yanyan Wang Dmytro Shytikov Yanwen Wang Wangyi Zhu Ruyi Chen Yuwei He Yanjia Yang Wei Guo 
supported by the National Natural Science Foundation of China(Nos.81974455,8217110405,and 82173351);the National Key Research and Development Program of China(No.2018YFA0107800);the Zhejiang University Startup Fund for Dr.Wei Guo.Special thanks also go to the Mu Xian Hua Stem Cells and Cancer Resistance Fund.
Therapeutic resistance in cancer is responsible for numerous cancer deaths in clinical practice.While target mutations are well recognized as the basis of genetic resistance to targeted therapy,nontarget mutation resi...
关键词：canonical NOTCH signaling noncanonical NOTCH signaling nongenetic resistance of cancer cancer stemlike cells epithelial-to-mesenchymal transition drug-tolerant persisters NOTCH inhibitors 
On the Necessary and Sufficient Conditions for Peng's Law of Large Numbers Under Sublinear Expectations
《Chinese Annals of Mathematics,Series B》2025年第1期139-150,共12页Xinpeng LI Gaofeng ZONG 
supported by the National Natural Science Foundation of China(Nos.12326603,11601281,11501325);the National Key R&D Program of China(No.2018YFA0703900);the Natural Science Foundation of Shandong Province(No.ZR2021MA018);the Social Science Planning Project of Shandong Province(No.24CJJJ18);the Qilu Scholars Program of Shandong University。
In this paper,the authors firstly establish the weak laws of large numbers on the canonical space(R^(N),B(R^(N)))by traditional truncation method and Chebyshev’s inequality as in the classical probability theory.Then...
关键词：Canonical space Independence and identical distribution Peng's law of large numbers Sublinear expectation 
本刊英文版2025年68卷第1期(1–252)摘要
《中国科学:数学》2025年第1期I0003-I0005,共3页
Miyaoka-type inequalities for terminal threefolds with nef anti-canonical divisors Masataka Iwai, Chen Jiang&Haidong Liu Abstract In this paper, we study Miyaoka-type inequalities on Chern classes of terminal projecti...
关键词：PROJECTIVE CANONICAL INEQUALITIES 
Modeling net-charge fluctuations in heavy-ion collisions at the LHC
《Chinese Physics C》2025年第1期281-289,共9页G.O.Ambaryan A.S.Chernyshov G.Kh.Eyyubova V.L.Korotkikh I.P.Lokhtin S.V.Petrushanko A.M.Snigirev E.E.Zabrodin 
supported by the BASIS Foundation(23-2-10-2-1)。
Analysis of Pb+Pb data for net-charge fluctuations at LHC energies using the HYDJET++model is presented.The strongly intensive quantities D and Σ were used to remove the effects related to system volume fluctuations....
关键词：relativistic heavy-ion collisions net-charge fluctuations strongly intensive variables canonical charge conservation 
BEZIER SPLINES INTERPOLATION ON STIEFEL AND GRASSMANN MANIFOLDS
《Journal of Computational Mathematics》2024年第6期1554-1578,共25页Ines Adouani Chafik Samir 
funded by the CNRS PRI.
We propose a new method for smoothly interpolating a given set of data points on Grassmann and Stiefel manifolds using a generalization of the De Casteljau algorithm.To that end,we reduce interpolation problem to the ...
关键词：OPTIMIZATION B´ezier spline Curve fitting Grassmann manifolds Stiefel manifolds Canonical metrics 
Breaking barriers:noncanonical inflammasome executes blood–brain barrier disruption
《Signal Transduction and Targeted Therapy》2024年第9期3541-3543,共3页Martin Dichgans Jonas J.Neher Yaw Asare 
supported by grants from the Deutsche Forschungsgemeinschaft(DFG,CRC 1123[B3],DI-722/16-1[ID:428668490],DI 722/21-1;Munich Cluster for Systems Neurology[SyNergy,EXC 2145]);a grant from the Leducq Foundation,and the Vascular Dementia Research Foundation.Y.Asare was supported by DFG(CRC 1123[B3],AS 575/1-1).
In a landmark study recently published in Nature,1 Wei and colleagues demonstrate that the activation of GSDMD by the cytosolic lipopolysaccharide(LPS)sensor caspase-11 triggers blood–brain barrier(BBB)breakdown upon...
关键词：inflam BARRIER CANONICAL 
Trace Lasso Regularization for Adaptive Sparse Canonical Correlation Analysis via Manifold Optimization Approach
《Journal of the Operations Research Society of China》2024年第3期573-599,共27页Kang-Kang Deng Zheng Peng 
supported by the National Science Foundation of China(No.12071398);the Natural Science Foundation of Hunan Province(No.2020JJ4567);the Key Scientific Research Found of Hunan Education Department(Nos.20A097 and 18A351).
Canonical correlation analysis(CCA)describes the relationship between two sets of variables by finding a linear combination that maximizes the correlation coefficient.However,in high-dimensional settings where the num...
关键词：Canonical correlation analysis Sparsity of canonical vectors Trace Lasso regularization Manifold optimization 
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