Mitochondrial cristae: lung cancer metabolism architects  

作　　者：Masafumi Noguchi Luca Scorrano 

机构地区：[1]Department of Biology,University of Padua,35121 Padua,Italy [2]Veneto Institute of Molecular Medicine,35129 Padua,Italy [3]Laboratory of Pharmacology,School of Pharmaceutical Sciences,Wakayama Medical University,25-1 Shichibancho,640-8156 Wakayama,Japan

出　　处：《Life Metabolism》2023年第2期1-3,共3页生命（代谢（英文）

摘　　要：In a recent study published in Nature,Shackelford and colleagues used an innovative in vivo mitochondrial morphology and bioenergetics analysis pipeline to correlate the metabolic signature of non-small cell lung cancer subtypes to the ultrastructure of mitochondria and their contact sites with lipid droplets.This study paves the way for diagnostic and therapeutic protocols for lung cancer based on the rationale assessment and modulation of mitochondrial topology and ultrastructure.Mitochondria are dynamic bioenergetic structures adapting their morphology to the varying cellular pathophysiological conditions.

关 键 词：METABOLISM lung RATIONAL 

分 类 号：R734.2[医药卫生—肿瘤]