A metabolic conspiracy drives anti-tumorigenic macrophages  

作　　者：Na Li Tiffany Horng 

机构地区：[1]School of Life Sciences and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《Life Metabolism》2023年第2期8-9,共2页生命（代谢（英文）

摘　　要：In the tumor microenvironment,activation of macrophages through CD40 ligation promotes tumor restriction and is being considered clinically.The underpinning metabolic basis is not known and was addressed in a new study by Ho and colleagues.Macrophage activation(or polarization)to distinct cellular states—that are associated with the acquisition of new cellular activities—is fueled by metabolic reprogramming.Intercepting such metabolic reprogramming can disrupt appropriate macrophage activation,thus there is increasing interest in targeting cellular metabolism to alter macrophage activities in a variety of pathophysiological settings[1].

关 键 词：metabolism tumor activation 

分 类 号：R730.3[医药卫生—肿瘤]