A nanoplatform self-assembled by coordination delivers siRNA for lung cancer therapy  

作　　者：Zi-Yao Wang Jie Mei Dong-Qi Ni Sheng-Mei Li Jin-Min Ye Shi-Lin Li Ya-Ling Wang Ying Liu 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,Beijing,100190,China [2]University of Chinese Academy of Sciences,Beijing,100049,China [3]GBA National Institute for Nanotechnology Innovation,Guangzhou,510700,China

出　　处：《Rare Metals》2023年第5期1483-1493,共11页稀有金属（英文版）

基　　金：financially supported by the Program for International S and T Cooperation Projects of the Ministry of Science and Technology of China (No.2018YFE0117200);the National Natural Science Foundation of China (No.31971318);the Special Project for Research and Development in Key Areas of Guangdong Province (No.2020B0101020001);the StrategicPriority Research Program of Chinese Academy of Sciences (No.XDB36000000)。

摘　　要：The high incidence and mortality of lung cancer have present threaten in front of people all over the world.Researches in clinical trials find that mutations of some genes influence progress of lung cancer directly or indirectly,therefore,some kinds of molecular inhibitors benefit patients in clinical therapy,which helpfully prolong survival time of patients and show great potential in lung cancer therapy.siRNA is a kind of nucleic acid molecules which can silence targeted gene translation through binding to mRNA completely to cure diseases.The delivery of siRNA for cancer therapy mostly can be classified into loading through electrostatic interaction,physical surrounding,and chemically modification.Yet delivering siRNA by coordination has not been reported.This study unprecedently utilizes the coordination between siRNA and Fe^(2+)to form a self-assembly structure in which doxorobicin(DOX) and human serum albumin(HSA) were used to stabilize the whole nanoplatform followed polyethylenimine(PEI) coating.Through the heat incubation strategy,highly loading efficiency for siRNA and DOX was achieved.This nanoplatform with stability and sustain release of drugs exhibited good lysosome escape,gene silencing effect and cytotoxicity which provided new horizon for co-deli very of siRNA and other molecular or protein drugs.

关 键 词：Lung cancer SIRNA COORDINATION NANOPARTICLES Drug delivery 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]