自噬在伴糖尿病牙周炎中的作用机制研究进展  

Research progress on the mechanism of autophagy in periodontitis with diabetic

作　　者：金伟秋 王敏 闫福华[1] 李艳芬 JINWei-qiu;WANG Min;YAN Fu-hua;LI Yan-fen(Department of Periodontology,Nanjing Stomatological Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属口腔医院·南京市口腔医院牙周病科,江苏南京210008

出　　处：《中国实用口腔科杂志》2023年第3期282-286,共5页Chinese Journal of Practical Stomatology

基　　金：江苏省卫生健康委医学科研项目(H2019033);江苏省科教能力提升工程-医学重点学科建设单位(JSDW202246)。

摘　　要：糖尿病是以高血糖为特征的全身低度炎症性疾病,是牙周炎的主要危险因素之一。糖尿病增加牙周炎的患病率和严重程度,并影响牙周治疗的预后。自噬是维持细胞质量的重要途径,与多种疾病有关,但与伴糖尿病牙周炎的关联机制尚需进一步确认。文章就自噬在伴糖尿病牙周炎中的作用机制进行总结,以期为未来探索通过调控细胞自噬来预防和治疗伴糖尿病牙周炎提供新的思路。Diabetes mellitus is a systemic low-grade inflammatory disease characterized by hyperglycemia,which is one of the main risk factors of periodontitis.Diabetes increases the prevalence and severity of periodontitis and affects the prognosis of periodontitis.Autophagy is an important way to maintain cell quality and is related to many diseases.But the association mechanism between autophagy and periodontitis with diabetic needs to be further confirmed.This article summarizes the mechanism of autophagy in periodontitis with diabetic in order to provide new ideas for the prevention and treatment of periodontitis with diabetic by regulating cell autophagy in the future.

关 键 词：糖尿病 牙周炎 自噬 炎症 免疫反应 牙槽骨吸收 

分 类 号：R78[医药卫生—口腔医学]