三维打印在牙周组织再生领域的应用研究进展  

Application of three-dimensional printing in periodontal tissue regeneration

作　　者：张平 曹洁[1] 胡文杰[1] ZHANG Ping;CAO Jie;HU Wen-jie(Department of Periodontology,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&National Health Commission Research Center of Engineering and Technology for Computerized Dentistry&Beijing Key Laboratory of Digital Stomatology,Beijing 100081,China;Qingdao Stomatological Hospital Affiliated to Qingdao University,Qingdao 266000,China;不详)

机构地区：[1]北京大学口腔医学院·口腔医院牙周科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔数字化医疗技术和材料国家工程实验室,国家卫生健康委员会口腔医学计算机应用工程技术研究中心,口腔数字医学北京市重点实验室,北京100081 [2]青岛大学附属青岛市口腔医院牙周科,山东青岛266000

出　　处：《中国实用口腔科杂志》2023年第3期364-369,共6页Chinese Journal of Practical Stomatology

基　　金：青岛市医疗卫生重点学科建设项目(2020-2022);青岛市口腔疾病临床医学研究中心(22-3-7-lczx-7-nsh);青岛市口腔医院青年基金项目(2018QN10)。

摘　　要：重度牙周炎会造成牙周组织的缺损,该疾病治疗的理想目标是实现缺损牙周组织的再生。应用三维打印的牙周组织再生支架和屏障膜有望规避传统治疗中的多种影响因素,为牙周组织再生带来新希望。三维打印支架在牙周组织再生领域的应用研究较为系统,动物实验中初步实现了牙槽骨-牙周膜-牙骨质复合体的再生,在功能特性方面达到了牙周膜纤维从无序到有序的排列,然而其三维打印仍面临着技术上的挑战,临床实施较为困难。在屏障膜方面的探索聚焦于如何构建多组分材料的复合膜及优化材料配比,从而提高其应用性能。文章以三维打印支架和屏障膜为重点对近年来三维打印在牙周组织再生领域中的应用研究进展和发展趋势进行介绍和梳理。Severe periodontitis could cause periodontal tissue defects.Therefore,the purpose of ideal periodontal therapy is to regenerate the entire periodontal tissue.The application of three-dimensional(3D)printing scaffolds and barrier membranes may overcome many difficulties in traditional treatment,and leding to major innovations in periodontal regeneration methods.Researches about the application of 3D printing scaffolds to periodontal tissue regeneration was systematic.In animal experiments the regeneration of periodontal complex(alveolar bone-periodontal ligament-cementum)has been initially realized,and the orderly structure of periodontal ligaments in function has also been achieved.However,3D printing scaffolds still have many technical limitations related to clinical application.The exploration of barrier membranes focuses on improving its performance by constructing multicomponent membranes and optimizing the material ratio.This article focuses on the scaffolds and barrier membranes and introduces the current application status and prospects of 3D printing in the regeneration of periodontal tissues in recent years.

关 键 词：三维打印 牙周组织再生 支架 屏障膜 

分 类 号：R78[医药卫生—口腔医学]