Microbial community structure of different tongue fur types in patients with chronic gastritis  

作　　者：WANG Yanan YUAN Li WANG Li XU Zhiyuan RUAN Hua CHENG Xiangdong DONG Changwu 

机构地区：[1]College of Traditional Chinese Medicine,Anhui University of Traditional Chinese Medicine,Hefei,Anhui 230000,China [2]Department of Surgery,Cancer Hospital Affiliated to the University of Chinese Academy of Sciences,Hangzhou 310022,China [3]Department of Surgery,Yuhang Hospital of Traditional Chinese Medicine,Hangzhou 310022,China

出　　处：《Journal of Traditional Chinese Medicine》2023年第2期365-373,共9页中医杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China:Study on the Mechanism of New Sophora Japonica Extract Inhibiting the Formation of Liver Pre Metastasis Microenvironment by Down Regulating the Gastric Cancer Cell-Derived Exosome ITGB5(No.81973634);Key Research And Development Plan of Anhui Province:Development And Application of TCM Health Status Identification System Based on Artificial Intelligence Tongue Diagnosis(No.2022h11020018);Key Projects of Anhui Provincial Department of Education:Research on Key Technologies of Artificial Intelligence Tongue Color Recognition Based on Machine Learning(No.KJ2020A0379)。

摘　　要：OBJECTIVE:To explore the correlation between tongue and oral microbiota,we studied the microbial community structure of different tongue coating types in patients with chronic gastritis.METHODS:16S rDNA gene sequencing and bioinformatics analysis were used to study the dynamic changes and correlation of microbial flora in patients with chronic gastritis,healthy people,and patients with different tongue fur.In addition,it was also discussed between the severity of gastritis and the microflora of tongue fur.RESULTS:The microbial diversity of tongue fur in patients with chronic gastritis was significantly different from healthy controls.There were significant changes in bacterial communities’diversity and relative abundance between extra tongue fur in patients but not in healthy people.Oral bacteria with relative abundance>1%and P<0.05 among different tongue fur flora were dominant bacteria,including 12 phyla such as Bacteroidetes,Proteobacteria and Firmicutes,and 256 genera such as Neisseria,Prevotella_7 and Haemophilus.CONCLUSIONS:The changes in oral flora in patients with chronic gastritis were related to tongue fur.Therefore,the significant microbiota might enlighten further study on the correlation between tongue inspection and oral microbiota in patients with chronic gastritis.

关 键 词：GASTRITIS medicine Chinese traditional RNA ribosomal 16S oral microflora tongue manifestation 

分 类 号：R573.3[医药卫生—消化系统]