老年性抑郁与脑白质疏松以及BDNF、NG相关性研究  

Study on the correlation between senile depression and leukoaraiosis,BDNF and NG

作　　者：杨泽华 刘波[2] 李帅 YANG Zehua;LIU Bo;LI Shuai(Inner Mongolia University of Science and Technology Baotou Medical College,Baotou 014010,China;The First Affiliated Hospital of Baotou Medical College)

机构地区：[1]包头医学院,内蒙古包头014040 [2]包头医学院第一附属医院

出　　处：《包头医学院学报》2023年第6期35-39,46,共6页Journal of Baotou Medical College

基　　金：包头医学院科学研究基金项目—秦文斌科技教育基金(BYJJ-QWB202008);2022年度自治区卫生健康科技计划项目(202202230)。

摘　　要：目的:探索老年性抑郁基于神经突触可塑性与脑白质疏松症(leukoaraiosis,LA)以及血清神经颗粒素(eurogranin,NG)、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)表达水平的相关性。方法:选取2020年10月-2021年6月我院收治的老年人抑郁为抑郁组(53例),另选取同期正常体检者设为非抑郁组(145例)。采用单因素及多因素Logistic回归分析老年性抑郁的危险因素,并采用Pearson相关性分析血清NG、BDNF水平、Fazekas评分与HAMD评分的关系。结果:抑郁组血清NG表达水平高于非抑郁组,血清BDNF表达水平低于非抑郁组(P<0.05);单因素分析显示,年龄、Fazekas评分、血清NG水平、BDNF水平与老年性抑郁相关;多因素Logistic回归分析显示,年龄、血清NG、BDNF血清水平均为老年性抑郁的独立影响因素(P<0.05)。Pearson相关性分析显示,血清NG水平与HAMD评分呈正相关(r=0.751,P<0.05),血清BDNF水平与HAMD评分呈负相关(r=-0.721,P<0.05),Fazekas评分与HAMD评分呈正相关(r=0.601,P<0.001),血清NG水平与Fazekas评分呈正相关(r=0.640,P<0.05)。结论:血清NG、BDNF表达异常可能基于神经突触可塑性介导老年性抑郁的发生;以及LA程度越重,则越容易发生老年性抑郁。Objective:To explore the correlation between of senile depression based on the expression levels of nerve synaptic plasticity and leukoaraiosis(LA),serum neurogranin(NG),brain derived neurotrophin(BDNF).Methods:The elderly patients with depression admitted to our hospital from October 2020 to June 2021 were selected as the depression group(53 patients),and the normal physical examinees during the same period were selected as the non-depression group(145 patients).Univariate and multivariate Logistic regression were used to analyze the risk factors of senile depression,and Pearson correlation was used to analyze the relationship between serum NG,BDNF level,Fazekas score and HAMD score.Results:The expression level of serum NG in the depression group was higher than that in the non-depression group,and the expression level of serum BDNF was lower than that in the non-depression group(P<0.05).Univariate analysis showed that age,Fazekas score,serum NG level and BDNF level were associated with senile depression.Multivariate Logistic regression analysis showed that age,serum levels of NG and BDNF were independent influencing factors of senile depression(P<0.05).Pearson correlation analysis showed that serum NG level was positively correlated with HAMD score(r=0.751,P<0.05),serum BDNF level was negatively correlated with HAMD score(r=-0.721,P<0.05),Fazekas score was positively correlated with HAMD score(r=0.601,P<0.001),and serum NG level was positively correlated with Fazekas score(r=0.640,P<0.05).Conclusion:Abnormal expression of serum NG and BDNF may mediate the occurrence of senile depression based on synaptic plasticity;and the more severe the degree of LA,the more prone to senile depression.

关 键 词：老年性抑郁 脑白质疏松 脑源性神经营养因子 神经颗粒素 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]