耐受性树突状细胞参与重建神经免疫性疾病中的T细胞平衡  

Tolerogenic dendritic cells involve in reconstructing T cell balance in neuroimmune conditions

作　　者：李若雨 李慧[1] 刘洪波[1] Li Ruoyu;Li Hui;Liu Hongbo(Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院神经内科,郑州450052

出　　处：《中华神经科杂志》2023年第6期714-720,共7页Chinese Journal of Neurology

基　　金：国家自然科学基金(U2004128);河南省省部级共建项目(SB201901018)。

摘　　要：树突状细胞是人体最强大的抗原提呈细胞,参与多发性硬化、视神经脊髓炎以及重症肌无力等多种神经免疫性疾病的发生和发展。近年来,具有免疫耐受特性的树突状细胞正逐渐成为神经免疫性疾病的研究热点和治疗靶点。它们通过诱导效应T细胞的无能和缺失,促进抗原特异性调节性T细胞的产生来重建T细胞平衡,最终达到维持免疫耐受的目的。文中从耐受性树突状细胞的关键免疫靶点出发,详细分析了神经免疫背景下耐受性树突状细胞重建T细胞平衡的主要机制,并总结了神经免疫性疾病中耐受性树突状细胞疗法相关的研究进展。Dendritic cells are the most powerful antigen-presenting cells in the human body,which are involved in the occurrence and development of multiple sclerosis,neuromyelitis optica,myasthenia gravis and other neuroimmune conditions.Recently,tolerogenic dendritic cells(tolDCs)are gradually becoming the research focus and therapeutic target of neuroimmune conditions.They can reconstruct the balance of T cells by inducing effector T cell anergy/deletion,and producing antigen-specific regulatory T cells,ultimately achieving the goal of maintaining immune tolerance.In this review,the mechanisms that tolDCs reconstruct T cell balance in neuroimmune conditions are analyzed and the research progress related to tolDC therapy is summarized.

关 键 词：树突细胞 T淋巴细胞 多发性硬化 视神经脊髓炎 重症肌无力 神经系统自身免疫疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]