H1-antihistamine use and head and neck cancer risk in type 2 diabetes mellitus  

作　　者：YI-NONG CHEN YING-LIN CHEN WAN-MING CHEN MINGCHIH CHEN BEN-CHANG SHIA JENQ-YUH KO SZU-YUAN WU 

机构地区：[1]Department of Otorhinolaryngology,Lo-Hsu Medical Foundation,Lotung Poh-Ai Hospital,Yilan,Taiwan,China [2]Graduate Institute of Business Administration,College of Management,Fu Jen Catholic University,Taipei,Taiwan,China [3]Artificial Intelligence Development Center,Fu Jen Catholic University,Taipei,Taiwan,China [4]Department of Otolaryngology,National Taiwan University Hospital and National Taiwan University College of Medicine,Taipei,Taiwan,China [5]Department of Food Nutrition and Health Biotechnology,College of Medical and Health Science,Asia University,Taichung,Taiwan,China [6]Division of Radiation Oncology,Lo-Hsu Medical Foundation,Lotung Poh-Ai Hospital,Yilan,Taiwan,China [7]Big Data Center,Lo-Hsu Medical Foundation,Lotung Poh-Ai Hospital,Yilan,Taiwan,China [8]Department of Healthcare Administration,College of Medical and Health Science,Asia University,Taichung,Taiwan,China [9]Cancer Center,Lo-Hsu Medical Foundation,Lotung Poh-Ai Hospital,Yilan,Taiwan,China [10]Centers for Regional Anesthesia and Pain Medicine,Taipei Municipal Wan Fang Hospital,Taipei Medical University,Taipei,Taiwan,China [11]Department of Management,College of Management,Fo Guang University,Yilan,Taiwan,China

出　　处：《Oncology Research》2023年第1期23-34,共12页肿瘤学研究（英文）

基　　金：Lo-Hsu Medical Foundation,LotungPoh-Ai Hospital,supports Szu-Yuan Wu’s work(Funding Numbers:10908,10909,11001,11002,11003,11006,and 11013).

摘　　要：This study aimed to examine the association between the use of H1-antihistamines(AHs)and head and neck cancer(HNC)risk in patients with type 2 diabetes mellitus(T2DM).Data from the National Health Insurance Research Database of Taiwan were analyzed for the period from 2008 to 2018.A propensity-score-matched cohort of 54,384 patients each in the AH user and nonuser groups was created and analyzed using Kaplan-Meier method and Cox proportional hazards regression.The results showed that the risk of HNC was significantly lower in AH users(adjusted hazard ratio:0.55,95%CI:0.48 to 0.64)and the incidence rate was also lower(5.16 vs.8.10 per 100,000 person-years).The lower HNC incidence rate in AH users(95%CI:0.63;0.55 to 0.73)suggests that AH use may reduce the risk of HNC in T2DM patients.

关 键 词：Type 2 diabetes H1-Antihistamine Head and neck cancer INCIDENCE Incidence rate 

分 类 号：R739.91[医药卫生—肿瘤]