脑脊液CXCL10:抗NMDAR脑炎潜在的生物学标志物  

Cerebrospinal fluid CXCL10: a valuable biomarker for anti-NMDAR encephalitis

作　　者：李夕凤 李红梅[1] LI Xifeng;LI Hongmei(Department of Neurology,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China)

机构地区：[1]山东大学齐鲁医院神经内科,山东济南250012

出　　处：《山东大学学报（医学版）》2023年第6期47-52,57,共7页Journal of Shandong University:Health Sciences

摘　　要：目的探讨抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎相关的炎性生物标志物,为临床提供帮助。方法收集18例抗NMDAR脑炎(抗NMDAR脑炎组)、12例抗富含亮氨酸胶质瘤失活蛋白1(LGI1)抗体脑炎(抗LGI1抗体脑炎组)、12例对照组患者的血清及脑脊液标本,采用酶联免疫吸附试验(ELISA)法检测各组血清及脑脊液C-X-C基序配体10(CXCL10)水平,采用SPSS 26.0软件进行数据统计分析,分别比较抗NMDAR脑炎组与对照组、抗LGI1抗体脑炎组与对照组、抗NMDAR脑炎组与抗LGI1抗体脑炎组脑脊液及血清CXCL10水平差异,分析CXCL10水平与抗NMDAR脑炎患者临床指标的相关性。结果抗NMDAR脑炎组脑脊液CXCL10水平明显高于对照组[168.29 pg/mL(126.74 pg/mL)vs 82.11 pg/mL(43.61 pg/mL),P=0.003],抗NMDAR脑炎组脑脊液CXCL10水平明显高于抗LGI1抗体脑炎组[168.29 pg/mL(126.74 pg/mL)vs 75.72 pg/mL(83.39 pg/mL),P=0.008]。抗NMDAR脑炎患者脑脊液CXCL10水平与脑脊液IgM水平呈正相关(相关系数rs=0.630,P=0.007)。结论脑脊液CXCL10是抗NMDAR脑炎潜在的生物标志物,且存在一定特异性。Objective To explore the inflammatory biomarkers related to anti-NMDAR encephalitis so as to provide clinical reference.Methods Serum and cerebrospinal fluid(CSF)samples were collected,including 18 cases with anti-NMDAR encephalitis(anti-NMDAR encephalitis group),12 cases with anti-leucine rich glioma inactivated 1 protein(LGI1)antibody encephalitis(anti-LGI1 antibody encephalitis group)and 12 cases in the control group.The CSF and serum levels of CXC-motif ligand 10(CXCL10)of all three groups were detected with enzyme linked immunosorbent assay(ELISA).Data obtained were analyzed with SPSS 26.0.The differences in CXCL10 level were analyzed,and the correlation between CXCL10 level and clinical indicators of anti-NMDAR encephalitis was assessed.Results The level of CXCL10 in CSF of anti-NMDAR encephalitis group was significantly higher than that of the control group[168.29 pg/mL(126.74 pg/mL)vs 82.11 pg/mL(43.61 pg/mL),P=0.003],and the anti-LGI1 antibody encephalitis group[168.29 pg/mL(126.74 pg/mL)vs 75.72 pg/mL(83.39 pg/mL),P=0.008].The CXCL10 level in patients with anti-NMDAR encephalitis was positively correlated with the IgM level(rs=0.630,P=0.007).Conclusion CXCL10 in CSF is a valuable biomarker with specificity for anti-NMDAR encephalitis.

关 键 词：抗N-甲基-D-天冬氨酸受体脑炎 抗富含亮氨酸胶质瘤失活蛋白1抗体脑炎 C-X-C基序配体10 脑脊液 

分 类 号：R574[医药卫生—消化系统]